Therapies for liver diseases

In one application of our hepatocyte targeting abilities, we have treated mice that were maintained on a high fat diet until they developed fatty liver disease with an hepatocyte-targeted thyroxine T3. Although nontargeted T3 induces a highly toxic activation of metabolism systemically, hepatocyte-targeted T3 stimulates fat metabolism only in the liver, thereby causing no systemic toxicity, while successfully treating fatty liver disease in only three weeks.