The Ghosh Laboratory

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Purdue University

 

Harnessing the Power of Organic Synthesis for Today's Medicine

In the Ghosh Research Labs, our graduate students and post-doctoral associates are utilizing the power of organic synthesis to address many challenging problems in today's medicine. Our research spans the areas of drug design and medicinal chemistry, natural product total synthesis, organometallic chemistry and new reaction development, to tackle diverse biological problems. We are located in the R. B. Wetherill Laboratory of Chemistry, a National Historic Chemical Landmark, on the Purdue University campus. 


FDA Approved Darunavir

In 2006, Darunvir received accelerated approval for HIV/AIDS patients harboring multidrug-resistant HIV-1 variants.  In 2008, darunavir received full approval for both treatment-naive and treatment-experienced HIV/AIDS patients. Darunavir is currently approved in over 80 countries and is used as first-line therapy.


BACE Inhibitor - Clinical Trials

BACE1 (β-secretase, memapsin 2) is a promising drug-development target for Alzheimer’s Disease.  Since its identification in 2000, our labs designed and developed many early inhibitors covering different structural classes. Inhibitor drug GRL-8234 rescues cognitive decline in mice with Alzheimer's Disease. Several BACE inhibitors from pharma labs are in advanced clinical trials.

Recent Publications

  • “Enantioselective total synthesis and structural assignment of callyspongiolide” A. K. Ghosh, L. A. Kassekert, J. D. Bungard Org. and Biomol. Chem. 2016, 14, 11357-11370. 
  • "Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-like Oxotricyclic Core as the P2-Ligand to Combat Multidrug-Resistant HIV Variants" A. K. Ghosh, K. V. Rao, P. R. Nyalapatla, H. L. Osswald, C. D. Martyr, M. Aoki, H. Hayashi, J. Agniswamy, Y.-F. Wang, H. Bulut, D. Das, I. T. Weber, H. Mitsuya J. Med. Chem. 2017, ASAP.

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