The Ghosh Laboratories:

The Home of the Backbone Binding, Bioactive Natural Product Synthesis, and Nature-Inspired Molecular Design for Today's Medicine

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Research in the Ghosh Laboratory


Research in the Ghosh laboratory focuses on organic synthesis for today's medicine. Our main areas of work are in structure-based drug design, total synthesis of natural products, and development of new asymmetric methodology. Please click any of the images above, or read on for more information.

High resolution X-Ray structure of Darunavir-Bound HIV-1 Protease (1.23 Å).Utilizing X-ray crystallographic data, we design novel classes of small-molecule inhibitors for HIV protease, an enzyme vital for the replication of infectious virions.

Last updated 2017

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X-ray Crystal Structure for Alzheimer's Disease ResearchOur structure-based design and synthesis of exceptionally potent ß-secretase inhibitor BACE1GRL-8234 penetrated the blood-brain-barrier (BBB), inhibitied plaque production in the brain and recued cognitive decline in transgenic Alzheimer's mice model.

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The total synthesis of various biologically important natural products is an important part of my group?s research. Our underlying interests include the development of new synthetic methodologies as well as the opportunity to establish important structure-function relationships for these rare natural products with medicinal significance... 

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We have developed a variety of new and useful asymmetric reactions based upon various intermolecular or intramolecular metal chelation. These include syn and anti specific aldol reactions, multicomponent reactions, inter- and intramolecular Diels-Alder reactions, conjugate additions, asymmetric protonation and reductions...

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