The Ghosh Laboratories:

The Home of the Backbone Binding, Bioactive Natural Product Synthesis, and Nature-Inspired Molecular Design for Today's Medicine

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Ghosh Group ยป About

About Professor Ghosh

  • 2009-Present: Ian P. Rothwell Distinguished Professor, Purdue UniversityProfessor Ghosh
  • 2005-2009: Professor, Department of Chemistry, Purdue University, West Lafayette, IN
  • 2005-2009: Professor, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN
  • 1998-2005: Professor, Department of Chemistry, University of Illinois at Chicago, Chicago, IL
  • 1997-1998: Associate Professor, Department of Chemistry, University of Illinois at Chicago, Chicago, IL
  • 1994-1997: Assistant Professor, Department of Chemistry, University of Illinois at Chicago, Chicago, IL
  • 1988-1994: Research Fellow, Merck Research Laboratories, West Point, PA
  • 1985-1988: Post-doctoral fellow (Professor E. J. Corey), Harvard University, Cambridge, MA
  • 1981-1985: Ph.D. Organic Chemistry, Dept. of Chemistry, University of Pittsburgh
  • 1979-1981: M.Sc. Organic Chemistry, Indian Institute of Technology, Kanpur, India
  • 1979: B.Sc. (Hons), Calcutta University, India


Highlights of Research Accomplishments:

Structure-based innovative molecular design:

  • Design and development of darunavir, an HIV-1 protease inhibitor drug approved for treating HIV-1 infection in treatment-naive and treatment-experienced patients.
  • Developed novel tools and strategies for protein X-ray structure based molecular design to combat drug-resistance. 
  • Structure based design and synthesis of potent and selective BACE1 (memapsin) inhibitors (β-secretase) for the treatment of Alzheimer’s disease.
  • Enzyme-inhibitor structure based design of selective BACE2 (memapsin 1) inhibitor for the treatment of type 2 diabetes.
  • Design and synthesis of natural-product inspired ligands and templates for HIV protease inhibitors based upon X-ray crystal structure of HIVP-inhibitor complexes, synthesized dipeptide transition-state isosteres.
  • Rational Design of peptidomimetic SARS-3CLPro inhibitors for SARS coronavirus.

Natural Products Total Synthesis and Biological Evaluation (62 total):

Synthesis of biologically important natural products with anticancer, antibacterial, antiviral, and antimalerial properties. Examples include the following:

Acetylaspidoalbidine

Amphidinolide T1

Amphidinolide W

Amphirionin-4

Alloyohimbane

Aetheramide A

AI-77-B

Amphidinolide W

Amphirionin-4

Arenastatin A

Boronolide

Brevisamide

Callyspongiolide

Cryptophycin 52

Cryptophycin B

Decytospolide A

Decytospolide B

Doliculide

Eburnamonine

Fendleridine

FR 252921

FR 901464

GEX1Q1

Griseoviridin

Hapalosin

Herboxidiene/GEX1A

Irimoteolide 1A

Irimoteolide 1B

Jasplakinolide

Lasonolide A

Largazole

Laulimalide

Lithospermic Acid

Madumycin II

Malyngolide

Hapalosin

Monocerin

Neopeltolide

Nucleosides Sinefungin

Tetrahydrolipstatin

Peloruside A

Peloruside B

Pladienolide B

Platencin

Platensimycin

Polyoxin C

Polyoxin J

Sinefungin

Spliceostatin A

Spliceostatin E

Spliceostatin G

Spliceostatin J

Spongidepsin

Stereocalpin A

Madumycin

Taurospongin A

Tetrahydrolipstatin

Thailanstatin A

Vincamon

Viridofungin A

Yohimbane

Zampanolide

 

 


Development of New Reactions and Asymmetric Technologies for Carbon-Carbon and Carbon-Hetero Atom BondFormation:
  • Stereoselective procedures for the asymmetric syn- and anti-Aldol reactions
  • Catalytic enantioselective Diels-Alder and hetero Diels-Alder reactions
  • Lewis-Acid mediated olefin migration and Prins cyclization to functionalized tetrahydropyrans
  • Asymmetric Achmatowicz reactions in synthesis
  • Novel methodologies for the multi-component coupling reactions
  • Development of specific reagents for alkoxycarbonylation of amines
  • Application of novel enzymatic reactions in synthesis
  • Novel applications of ring closing olefin metathesis in synthesis


Office telephone: (765) 494-5323
e-mail: akghosh@purdue.edu

Operations Manager: Suzy Snoeberger
Office telephone: (765) 494-5300
e-mail: svantwo@purdue.edu