The Ghosh Laboratories:
The Home of the Backbone Binding, Bioactive Natural Product Synthesis, and Nature-Inspired Molecular Design for Today's Medicine
List of US Patents and Applications (Total of 70)
70. US-11851441-B2, Anti-cancer agents and preparation thereof, A. K. Ghosh, Issued: December 2023
69. US-20230399338-A1, METHOD OF SYNTHESIZING (3S,3AR,5R,7AS,8S)- HEXAHYDRO-4H-3,5-METHANOFURO[2,3-b]PYRAN-8-OL, A. K. Ghosh, S. Markad, Issued: December 2023
68. US-11834408-B2, Compounds for the treatment of SARS, A. K. Ghosh, M. Yadav, A. Mesecar, Issued: December 2023
67. US-11807631-B2, Herboxidiene derivatives and uses thereof, A. K. Ghosh, M. Jurica, Issued: November 2023
66. US-11795159-B2, Compounds for the treatment of SARS, A. K. Ghosh, H. Mitsuya, A. Mesecar, D. Shahabi, Issued: October 2023
65. US-20230192671-A1, COMPOUNDS FOR THE TREATMENT OF SARS, A. K. Ghosh, H. Mitsuya, A. Mesecar, Issued: June 2023
64. US-20230183207-A1, COMPOUNDS FOR THE TREATMENT OF SARS, A. K. Ghosh, H. Mitsuya, Issued: June 2023
63. US-20230159516-A1, COMPOUNDS FOR THE TREATMENT OF SARS, A. K. Ghosh, H. Mitsuya, M. Yadav, A. Mesecar, Issued: May 2023
62. US-20230136594-A1, TRICYCLIC P2-LIGAND CONTAINING POTENT HIV-PROTEASE INHIBITORS, A. K. Ghosh, H. Mitsuya, S. Kovela, Issued: May 2023
61. US-20220411401-A1, COMPOUNDS FOR THE TREATMENT OF SARS, A. K. Ghosh, H. Mitsuya, A. Mesecar, D. Shahabi, Issued: December 2022
60. US-20220396550-A1, COMPOUNDS FOR THE TREATMENT OF SARS, A. K. Ghosh, M. Yadav, A. Mesecar, Issued: December 2022
59. US-20220389030-A1, BACE1 INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE, A. K. Ghosh, A. Mesecar, M. Brindisi, E. L. Cardenas, Issued: December 2022
58. US-20220363688-A1, HIV-1 PROTEASE INHIBITORS AND USES THEREOF, A. K. Ghosh, H. Mitsuya, S. Kovela, Issued: November 2022
57. US-11390630-B2, Tricyclic P2-ligand containing potent HIV-protease inhibitors against HIV/AIDS, A. K. Ghosh, H. Mitsuya, P. R. Nyalapatla, Issued: July 2022
56. US-11230550-B2, Macrocyclic HIV-1 protease inhibitors and uses thereof, A. K. Ghosh, H. Mitsuya, M. Brindisi, S. Fyvie, Issued: January 2022
55. US-11214579-B2, BACE1 inhibitors for the treatment of Alzheimer's disease, A. K. Ghosh, A. Mesecar, M. Brindisi, E. L. Cardenas, Issued: January 2022
54. US-20210395265-A1, ANTI-CANCER AGENTS AND PREPARATION THEREOF, A. K. Ghosh, Issued: December 2021
53. US-20210261563-A1, TRICYCLIC P2-LIGAND CONTAINING POTENT HIV-PROTEASE INHIBITORS AGAINST HIV/AIDS, A. K. Ghosh, H. Mitsuya, P. R. Nyalapatla, Issued: August 2021
52. US-11028096-B2, Tricyclic P2-ligand containing potent HIV-protease inhibitors against HIV/AIDS, A. K. Ghosh, H. Mitsuya, P. R. Nyalapatla, Issued: June 2021
51. US-10875836-B2, Callyspongiolide, analogs thereof and uses thereof, A. K. Ghosh, L. A. Kassekert, Issued: December 2020
50. US-10858371-B2, Anti-cancer agents and preparation thereof, A. K. Ghosh, Issued: December 2020
49. US-20200299308-A1, BACE1 INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE, A. K. Ghosh, A. Mesecar, M. Brindisi, E. L. Cardenas, Issued: September 2020
48. US-20200207746-A1, HERBOXIDIENE DERIVATIVES AND USES THEREOF, A. K. Ghosh, M. Jurica, Issued: July 2020
47. US-20200165264-A1, MACROCYCLIC HIV-1 PROTEASE INHIBITORS AND USES THEREOF, A. K. Ghosh, H. Mitsuya, M. Brindisi, S. Fyvie, Issued: May 2020
46. US-20190359626-A1, TRICYCLIC P2-LIGAND CONTAINING POTENT HIV-PROTEASE INHIBITORS AGAINST HIV/AIDS, A. K. Ghosh, H. Mitsuya, P. R. Nyalapatla, Issued: November 2019
45. US-10472372-B2, HIV-1 protease inhibitors and uses thereof, A. K. Ghosh, H. Mitsuya, Issued: November 2019
44. US-20190218198-A1, CALLYSPONGIOLIDE, ANALOGS THEREOF AND USES THEREOF, A. K. Ghosh, L. A. Kassekert, Issued: July 2019
43. US-20190218228-A1, ANTI-CANCER AGENTS AND PREPARATION THEREOF, A. K. Ghosh, Issued: July 2019
42. US Patent: 9808527. Methods and Compositions for Treating HIV Infections. A. K. Ghosh, H. Mitsuya, Y. Koh. Issued: November 7, 2017
41. US Patent: 9670225. HIV-1 Protease Inhibitors and Uses Thereof. A. K. Ghosh, V. R. Kalapala, H. Mitsuya. Issued: June 6, 2017.
40. US Patent: 9617276. Compounds and Methods for treating AIDS and HIV Infections. A. K. Ghosh. Issued: April 11, 2017.
39. US Patent: 9512099. Compounds for Inhibition of Memapsin 1. A. K. Ghosh. Issued: December 6, 2016.
38. US Patent: 9499558. Compounds and Methods for treating HIV. A. K. Ghosh, B. D. Chapsal, H. Mitsuya, C. D. Martyr. Issued: November 22, 2016.
37. US Patent: 9487541. Fused Tricyclic Ether Carbamates and their Use. A. K. Ghosh, C.-X. Xu, H. Mitsuya, G. Partham. Issued: November 8, 2016.
36. US Patent: 9359317. Small molecule inhibitors of HIV proteases. A. K. Ghosh. Issued: June 7, 2016.
35. US Patent: 9346820. HIV-1 protease inhibitors having Gem-difluoro bicyclic P2-ligands. A. K. Ghosh, H. Mitsuya, S. Yashchuk. Issued: May 24, 2016.
34. US Patent: 9309213. C-3 substituted Bicyclooctane based HIV protease inhibitors. A. K. Ghosh, H. Mitsuya, B. D. Chapsal. Issued: April 12, 2016.
33. US 20150072958, A. Ghosh, H. Mitsuya, S. Yashchuk. Preparation of gem-difluoro heterobicyclic compounds as HIV-1 protease inhibitors U.S. Pat. Appl. Publ. 2015.
32. US Patent : 9096541. Inhibition of memapsin 1 cleavage in the treatment of diabetes. J. Tang, X. Huang, D. Downs, A. K. Ghosh. Issued, August 4, 2015
31. US Patent : 9085571. Nonpeptide HIV-1 protease inhibitors. A. Ghosh. Issued, July 21, 2015
30. US Patent: 9062057. CCR5 antagonists for treating HIV. A. K. Ghosh, H. Mitsuya, K. Venkateswararao, J. Li. Issued, June 23, 2015
29. US Patent: 9024038. Compunds and methods for treating HIV . A. K. Ghosh, B. D. Chapsal, H. Mitsuya, C. D. Martyr. Issued: May 5, 2015
28. US Patent: 8921349. Compounds and methods for treating AIDS and HIV infections. A. K. Ghosh. Issued, December 30, 2014
27. US Patent: 8859590. Inhibitors of BACE1 and methods for treating Alzheimer's disease. A. K. Ghosh. Issued, October 14, 2014.
26. US Patent: 8802724. Processes and intermediates for preparing substituted hexahydrofuro [2,3-b] furans. A. K. Ghosh, C. D. Martyr. Issued: August 12, 2014.
25. US Patent: 8791135. Nonpeptide HIV-1 protease inhibitors. A. K. Ghosh. Issued: July 29, 2014.
24. US Patent: 8703947. A. K. Ghosh; “Compounds for the treatment of Alzheimer’s Disease” Issued April 22, 2014.
23. US Patent: 8580975. A. K. Ghosh; X. Xu;”Synthesis of Macrocyclic Cancer Chemotherapeutic agents” Issued November 12, 2013.
22. US Patent: 8501961 - A. K. Ghosh. “HIV-1 protease inhibitors and methods thereof for treatment of HIV/AIDS” Issued August 6, 2013.
21. US Patent: 8563597. A. K. Ghosh; C.-X. Xu; H. Mitsuya; G. Parham;” Fused tricyclic ether carbamates for treating HIV infected patients” Issued October 22, 2013.
20. US Patent: 83394807. A. K. Ghosh;”Quinazoline inhibitors of BACE 1 and methods of using for treatment of Alzheimer's disease” Issued March 23, 2013.
19. US Patent: 8278100. Y. Pommier; Y. Zhang; A. K. Ghosh;” Lasonolide compounds as reagents for inducing premature chromosome condensation and methods for treating disorders” Issued, October 22, 2012.
18. US Patent: 8299267. A. K. Ghosh;” Preparation of pyrrolidine benzamide for the treatment of Alzheimer's disease” Issued, October 17, 2012.
17. US Patent: 8779268. G. M. Bilcer; T. Devasamudram; S. V. Ankala; J. C. Lilly; C. Liu; H. Lei; A. K. Ghosh; M. Inoue; “Pyrrolidine compounds as inhibitors of beta-secretase activity and their preparation and use in the treatment of Alzheimer's disease” PCT Int. Appl. 2010.
16. US Patent: 7504420. A. K. Ghosh. Beta-secretase inhibitors and methods of use thereof. Issued May 11, 2009.
15. US Patent: 7470506B1 – Erickson, J. W.; Gulnik, S. V.; Mitsuya, H.; Ghosh, A. K. Fitness Assay and Associated Methods. Issued December 30, 2008.
14. US Patent: 7,335,632 – A. K. Ghosh, H. Lei, T. Devasamudram, C. Liu, J. Tang, G. Bilcer. Beta-secretase inhibitors and methods of use thereof. Issued February 26, 2008.
13. US 20100113582 A1 – A. K. Ghosh, Methods and compositions for treating HIV infections. November 20, 2007.
12. US Patent: 7,244,708 – J. Tang and A. K. Ghosh. Inhibitors of memapsin 2 and use thereof. Issued July 17, 2007.
11. US Patent: 7,157,489 – A. K. Ghosh, G. Bilcer, T. Devasamudram. HIV protease inhibitors. Issued January 2, 2007.
10. US Patent: 6,500,100.P1., A. K. Ghosh, X. Xu, – “Synthesis of novel anticancer agent Peloruside A and its analogs”, filed November, 2007.
9. US Patent: 7,109,235 – A. K. Ghosh. Microtubule stabilizing compounds and their treatment of cancers. Issued September 19, 2006.
8. US patent:7,504,420 – Ghosh, A. K., Kumaragurubaran, N., Liu, C., Devasamudram, T., Lei, H., Swanson, L., Ankala, S., Tang, J., Bilcer, G. Preparation of benzene-1,3-dicarboxamides which inhibit beta-secretase activity. Issued December 1, 2006.
7. US Patent: 6,919,465 - A. K. Ghosh, M. Noetzl, and S. Leshchenko. Method of preparing (3R,3aS,6aR)-3-hydroxyhexahydrofuro[2,3-b]furan and related compounds. Issued July 19, 2005.
6. US Patent: 6,969,731 – J. Tang and A. K. Ghosh. Protease inhibitors that overcome drug resistance. Issued November 29, 2005.
5. US Patent: 7,659,289 – A. K. Ghosh, H. Lei, T. Devasamudram, J. Tang, G. Bilcer, C. Liu, Beta-secretase inhibitors and methods of use thereof. Issued February 26, 2005.
4. US Patent:7,829,669 - Tang, J., Koelsch, G., Ghosh, A. K., Hong, L. Lin, X. Catalytically active recombinant memapsin and methods of use thereof. Issued December 1, 2005.
3. US Patent: 6,969,731– Ghosh, A. K.; Tang, J. “Protease Inhibitors that overcome Resistance” B1, Issued November 29, 2005..
2. US Patent: 7,390,826– Fenteany, G.; Ghosh, A. K.; McHenry, K.; Ankala, S.; Anjum, S.; Zhu, S. “2-Oxazolidinones and their use as inhibitors of animal cell motility and growth.” Issued March 13, 2003.
1. US Patent: 5,502,060 –Thompson, W. J.; Ghosh, A. K.; Huff, J. R. Oligopeptide analogs in the inhibition of HIV protease, Issued June 10, 1998.