The Ghosh Laboratories:

The Home of the Backbone Binding, Bioactive Natural Product Synthesis, and Nature-Inspired Molecular Design for Today's Medicine

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Ghosh Group ยป Research Publications

Research Publications (total of 385)

2022

385. "Asymmetric 1,2-Carbamoyl Rearrangement of Lithiated Chiral Oxazolidine Carbamates and Diastereoselective Synthesis of a-Hydroxy Amides," A. K. Ghosh, A. J. Basu, C.-S. Hsu, M. Yadav, Chem. - Eur. J. 2022, 28, e202200941.

384. "Total Syntheses of the Proposed Structure of Iriomoteolide-1a, -1b and Synthesis of Three Derivatives for Structural Studies," A. K. Ghosh, H. Yuan, Marine Drugs, 2022, 20, 587.

383. "Beyond Darunavir: Recent Development of Next Generation HIV-1 Protease Inhibitors to Combat Drug Resistance," A. K. Ghosh, I. T. Weber, H. Mitsuya, ChemComm, 2022, ASAP.

382. "Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS-CoV-2 and Covid-19," A. K. Ghosh, J. L. Mishevich, A. Mesecar, H. Mitsuya, ChemMedChem, 2022, ASAP.

381. "A Convenient Synthesis of (3S,3aR,5R,7aS,8S)-Hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-ol, a High-Affinity Nonpeptidyl Ligand for Highly Potent HIV-1 Protease Inhibitors," A. K. Ghosh, S. Markad, Tetrahedron Letters, 2022, ASAP. 

380. "HIV-1 Protease with 10 Lopinavir and Darunavir Resistance Mutations Exhibits Altered Inhibition, Structural Rearrangements and Extreme Dynamics," A. Wong-Sam, Y.-F. Wang, D. W. Kneller, A. Y. Kovalevsky, A. K. Ghosh, R. W. Harrison, I. T. Weber, J. Mol. Graph. Model. 2022, 117, 108315.

379. "Convergent synthesis of (+)-carambolaflavone A, an antidiabetic agent using a bismuth triflate-catalyzed C-aryl glycosylation," A. K. Ghosh, W. L. Robinson, J. Gulliver, H. M. Simpson, Org. Biomol. Chem. 2022, 20, 2822-2830.

378. "Highly Diastereoselective asymmetric syn-aldol reactions of (R)-(N-tosyl)phenylalaninol propionate-derived titanium enolate and bidentate aromatic and aliphatic aldehydes," A. K. Ghosh, J. P. Gulliver, Tetrahedron Letters2022, 102, 153954. 

377. "Design, Synthesis and X-ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-furofuran derivatives as P2 ligands," A. K. Ghosh, S. Kovela, A. Sharma, D. Shahabi, A. K. Ghosh, D. R. Hopkins, M. Yadav, M. E. Johnson, J. Agniswamy, Y.-F. Wang, M. Aoki, M. Amano, I. T. Weber, H. Mitsuya ChemMedChem, 2022, 17, e202200058. 

376. "Fluorine-Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier (BBB) Penetration Property of Novel Central Nervous System (CNS)-targeting HIV-1 Protease Inhibitors In Vitro," M. Amano, R. S. Yedidi, P. M. Salcedo-Gomez, H. Hayashi, K. Hasegawa, C. D. Martyr, A. K. Ghosh, H. Mitsuya Antimicrob. Agents Chemother. 2022, 66, e01715-21.

2021

375. "Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies," A. K. Ghosh, J. Raghavaiah, D. Shahabi, M. Yadav, B. J. Anson, E. K. Lendy, S.-i. Hattori, N. Higashi-Kuwata, H. Mitsuya, A. D. Mesecar. J. Med. Chem. 2021, 64, 14702-14714. 

374. "Enantioselective Total Synthesis of (+)-EBC-23, a Potent Anticancer Agent from the Australian Rainforest," A. K. Ghosh, C.-S. Hsu, J. Org. Chem. 2021, 86, 6351-6360. 

373. "Highly Diastereoselective Intramolecular Asymmetric Oxidopyrylium-olefin [5+2] Cycloaddition and Synthesis of 8-Oxabicyclo[3.2.1]oct-3-enone Containing Ring System," A. K. Ghosh, M. Yadav, J. Org. Chem. 2021, 86, 8127-8142. 

372. "Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors," C. Cretu, P. Gee, X. Liu, A. Agrawal, T.-V. Nguyen, A. K. Ghosh, A. Cook, M. Jurica, N. A. Larsen, V. Pena, Nature Comm. 2021, 12, 4491.

371. "Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CLpro Protease Inhibitors," A. K. Ghosh, D. Shahabi, M. Yadav, S. Kovela, B. J. Anson, E. K. Lendy, C. Bonham, D. Sirohi, C. A. Brito-Sierra, S.-i. Hattori, R. Kuhn, H. Mitsuya, A. D. Mesecar, Molecules2021, 26, 5782.

370. "U2 snRNA structure is influenced by SF3A and SF3B proteins but not by SF3B inhibitors," V. K. Urabe, M. Stevers, A. K. Ghosh, M. S. Jurica PLOS One 202116, e0258551.

369. "Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors" A. K. Ghosh, J. L. Mishevich, M. S. Jurica, J. Nat. Prod. 2021, 84, 1681-1706.

368. "Design and Synthesis of Herboxidiene Derivatives that Potently Inhibit In Vitro Splicing" A. K. Ghosh, S. R. Allu, G. C. Reddy, A. G. Lopez, P. Mendez, M. S. Jurica, Org. & Biomol. Chem. 202119, 1365-1377. 

367. "Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluorobenzyl target the two active site mutations of highly drug resistant mutant PRS17" J. Agniswamy, D. W. Kneller, A. K. Ghosh, I. T. Weber, Biochem. & Biophys. Res. Comm. 2021566, 30-35.

366. "A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication" S.-i. Hattori, N. Higashi-Kuwata, H. Hayashi, S. R. Allu, J. Raghavaiah, H. Bulut, D. Das, B. J. Anson, E. K. Lendy, Y. Takamatsu, N. Takamune, N. Kishimoto, K. Murayama, K. Hasegawa, M. Li, D. A. Davis, E. N. Kodama, R. Yarchoan, A. Wlodawer, S. Misumi, A. D. Mesecar, A. K. Ghosh, H. Mitsuya, Nature Comm. 2021, 12, 668.

365. "Herboxidiene features that Mediate Conformation-Dependent SF3B1 Interactions to Inhibit Splicing" A. G. Lopez, S. R. Allu, P. Mendez, G. C. Reddy, H. M. Maul-Newby, A. K. Ghosh, M. S. Jurica ACS Chem. Biol. 2021, 16, 520-528.

364. "Synthesis of amide derivatives for electron deficient amines and functionalized carboxylic acids using EDC and DMAP and a catalytic amount of HOBt as the coupling reagents" A. K. Ghosh, D. Shahabi, Tetrahedron Letters 2021, 63, 152719. 

363. "The Chiron Approach to (3R,3aS,6aR)Hexahydrofuro[2,3b]furan-3-ol, a Key Subunit of HIV-1 Protease Inhibitor Drug, Darunavir" A. K. Ghosh, S. B. Markad, W. L. Robinson, J. Org. Chem. 2021, 86, 1216-1222. 

362. "A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors" Y.-C. Yen, A. M. Kammeyer, J. Tirlangi, A. K. Ghosh, A. D. Mesecar, ACS Chem. Neuroscience 2021, 12, 581-588.  

2020

361. "GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection" S.-i. Hattori, N. Higshi-Kuwata, J. Raghavaiah, D. Das, H. Bulut, D. A. Davis, Y. Takamatsu, K. Matsuda, N. Takamune, N. Kishimoto, T. Okamura, S. Misumi, R. Yarchoan, K. Maeda, A. K. Ghosh, H. Mitsuya, mBio 202011, e01833-20.

360. "A Copper-Catalyzed Stille Cross-Coupling Reaction and Application in the Synthesis of the Spliceostatin Core Structure" A. K. Ghosh, J. R. Born, A. M. Veitschegger, M. S. Jurica, J. Org. Chem. 2020, 85, 8111-8120.

359. "Drug Development and Medicinal Chemistry Efforts Toward SARS-Coronavirus and Covid-19 Therapeutics" A. K. Ghosh, M. Brindisi, D. Shahabi, M. E. Chapman, A. D. Mesecar, ChemMedChem 2020, 15, 907-932.

358. "Structure-Based Design of Highly Potent HIV1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design Synthesis, Biological, and Xray Structural Studies" A. K. Ghosh, S. Kovela, H. L. Osswald, M. Amano, M. Aoki, J. Agniswamy, Y.-F. Wang, I. T. Weber, H. Mitsuya, J. Med. Chem., 2020, 63, 4867-4879.

357. "Lewis Acid-Catalyzed Vinyl Acetal Rearrangement of 4,5-Dihydro-1,3-dioxepines: Stereoselective Synthesis of cis- and trans-2,3-Disubstituted Tetrahydrofurans" A. K. Ghosh, M. R. Belcher J. Org. Chem., 2020, 85, 10399-10412.

356. "Single Atom Changes in Newly Synthesized HIV Protease Inhibitors Reveal Structural Basis for Extreme Affinity, High Genetic Barrier, and Adaptation to the HIV Protease Plasticity" H. Bulut, S.-i. Hattori, H. Aoki-Ogata, H. Hayashi, D. Das, M. Aoki, D. A. Davis, K. V. Rao, P. R. Nyalapatla, A. K. Ghosh, H. Mitsuya, Sci. Rep., 2020, 10, 10664.

355. "Design, Synthesis and X-ray Studies of Potent HIV-1 Protease Inhibitors with P2-Carboxamide Functionalities" A. K. Ghosh, A. Grillo, J. Raghavaiah, S. Kovela, M. E. Johnson, D. W. Kneller, Y.-F. Wang, S.-i. Hattori, N. Higashi-Kuwata, I. T. Weber, and H. Mitsuya ACS Med. Chem. Lett. 2020, 11, 1965-1972.

354. “Fluorescent Probes for Monitoring Serine Ubiquitination" K. Puvar, A. M. Saleh, R. W. Curtis, Y. Zhou, P. R. Nyalapatla, J. Fu, A. R. Rovira, Y. Tor, Z.-Q. Luo, A. K. Ghosh, M. J. Wirth, J. Chmielewski, T. L. Kinzer-Ursem, C. Das. Biochemistry 2020, 59, 1309−1313.

353. "Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry" A. K. Ghosh, M. Brindisi J. Med. Chem. 2020, 63, 2751-2788.

2019

352. "Enantioselective Total Syntheses of (+)-Fendleridine and (+)-Acetylaspidoalbidine" A. K. Ghosh, J. R. Born, L. A. Kassekert J. Org. Chem. 2019, 84, 5167-5175.

351. "Enantioselective Total Synthesis of (+)-Monocerin, a Dihydroisocoumarin Derivative with Potent Antimalarial Properties" A. K. Ghosh, D. S. Lee J. Org. Chem. 2019, 84, 6191-6198.

350. "Asymmetric Diels-Alder reaction of 3-(acyloxy)acryloyl oxazolidinones: optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors" A. K. Ghosh, A. Grillo, S. Kovela, M. Brindisi RSC Advances, 2019, 9, 41755-41763. 

349. "A Photochemical Route to Optically Active Hexahydro-4H-furopyranol, a High-Affinity P2 Ligand for HIV-1 Protease Inhibitors" A. K. Ghosh, W. L. Robinson J. Org. Chem. 201984, 9801-9805.

348. "Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation" A. K. Ghosh, J. N. Williams, S. Kovela, J. Takayama, H. M. Simpson, D. Eric Walters. S.-i. Hattori, M. Aoki, H. Mitsuya, Bioorg. & Med. Chem. Lett. 201929, 2565-2570. 

347. "Highly Selective and Potent Human beta-Secretase 2 (BACE2) Inhibitors Against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies" A. K. Ghosh, M. Brindisi, Y.-C. Yen, E. K. Lendy, S. Kovela, E. L. Cardenas, B. S. Reddy, K. V. Rao, D. Downs, X. Huang, J. Tang, A. D. Mesecar ChemMedChem 201914, 545-560.

346. "A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance" M. Aoki, S. B. Chang, D. Das, C. Martyr, N. S. Delino, Y. Takamatsu, A. K. Ghosh, H. Mitsuya Global Health & Med. 2019, 1, 36-48.

345. "Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and X-ray Structural Studies of Inhibitor HIV-1 Protease Complex" A. K. Ghosh, Z. Xia, S. Kovela, W. Robinson, M. E. Johnson, J. Agniswamy, Y.-F. Wang, M. Aoki, M. Amano, I. T. Weber, H. Mitsuya ChemMedChem 2019, 14, 1863-1872.

344. "Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors" Y.-C. Yen, A. M. Kammeyer, K. C. Jensen, J. Tirlangi, A. K. Ghosh, A. D. Mesecar Biochemistry 2019, 58, 4424-4435.

343. "Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s" H. Nakata, K. Maeda, D. Das, S. B. Chang, K. Matsuda, K. V. Rao, S. Harada, K. Yoshimura, A. K. Ghosh, H. Mitsuya Sci Rep. 2019, 9, 4828.

342. "Halogen bond interactions of novel HIV-1 protease inhibitors (PI) (GRL-001-15 and GRL-003-15) with the flap of protease are critical for their potent activity against wild-type and multi-PI-resistant HIV-1 variants" S. I. Hattori, H. Hayashi, H. Bulut, K. V. Rao, P. R. Nyalapatla, K. Hasegawa, M. Aoki, A. K. Ghosh, H. Mitsuya Antimicrob. Agents. Chemother. 2019, 63, e02635-18.

341. "Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V821" S. Pawar, Y.-F. Wang, A. Wong-Sam, J. Agniswamy, A. K. Ghosh, R. W. Harrison, I. T. Weber Biochem. and Biophys. Res. Comm. 2019, 514, 974-978. 

340. "Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications." M. Amano, P. M. Salcedo-Gomez, R. S. Yedidi, R. Zhao, H. Hayashi, K. Hasegawa, T. Nakamura, C. D. Martyr, A. K. Ghosh, H. Mitsuya Antimicrob. Agents Chemother. 2019, 63, e00466-19.

339. "Novel protease inhibitors containg C-5-modified bis-THF and aminobenzothiazole as P2 and P2' ligands that exert potent antiviral activity against highly multidrug-resistant HIV-1 with high genetic barrier against the emergence of drug resistance." Y. Takamatsu, M. Aoki, H. Bulut, D. Das, M. Amano, V. R. Sheri, L. C. Kovari, H. Hayashi, N. S. Delino, A. K. Ghosh, H. Mitsuya Antimicrob. Agents Chemother. 2019, 68, e00372-19.

2018

338. "Enantioselective Synthesis of a Cyclopropane Derivative of Spliceostatin A and Evaluation of Bioactivity" A. K. Ghosh, G. C. Reddy, S. Kovela, N. Relitti, V. K. Urabe, B. E. Prichard, M. S. Jurica Org. Lett. 2018, 20, 7293-7297.

337. "Design and Synthesis of Potent HIV-1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2-Ligands: Structure-Activity Studies, Biological and X-ray Structural Studies" A. K. Ghosh, J. Williams, R. Ho, H. Simpson, S. Hattori, H. Hayashi, J. Agniswamy, Y.-F. Wang, I. T. Weber, H. Mitsuya J. Med. Chem. 2018, 61, 9722-9737.

336. "Design, Synthesis, and X-ray Studies of Potent HIV-1 Protease Inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands." A. K. Ghosh, R. D. Jadhav, H. Simpson, S. Kovela, H. Osswald, J. Agniswamy, Y.-F. Wang, S. i. Hattori, I. T. Weber, H. Mitsuya. Eur. J. Med. Chem. 2018, 160, 171-182.

335. "Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition" A. K. Ghosh, A. M. Veitschegger, S. Nie, N. Relitti, A. J. MacRae, M. S. Jurica. J. Org. Chem. 201883, 5187-5198.

334. "Enantioselective Total Synthesis of Decytospolide A and Decytospolide B Using An Achmatowicz Reaction" A. K. Ghosh, H. M. Simpson, A. M. Veitschegger Org. & Biomol. Chem. 2018, 16, 5979-5986.

333. "Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV-1 Protease Inhibitors" A. K. Ghosh, M. Brindisi, Asian J. Org. Chem. 2018, 7, 1448-1466.

332. "Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand" A. K. Ghosh, K. Ghosh, M. Brindisi, E. K. Lendy, Y.-C. Yen, N. Kumaragurubaran, X. Huang, J. Tang, A. D. Mesecar Bioorg. & Med. Chem. Lett. 2018, 28, 2605-2610.

331. "The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry" A. K. Ghosh, M. Brindisi, A. Sarkar, ChemMedChem 2018, 13, 2351-2373.

330. "Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease" A. Wong-Sam, Y.-F. Wang, Y. Zhang, A. K. Ghosh, R. W. Harrison, I. T. Weber ACS Omega, 2018, 3, 12132-12140.

329. "Differentiating Isomeric Deprotonated Glucuronide Drug Metabolites via Ion/Molecule Reactions in Tandem Mass Spectrometry" J. Y. Kong, Z. Yu, M. W. Easton, E. Niyonsaba, X. Ma, R. Yerabolu, H. Sheng, T. M. Jarrell, Z. Zhang, A. K. Ghosh, H. I. Kenttamaa Anal. Chem. 2018, 7, 9426-9433.

328. "Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure–Activity Studies, Biological and X-ray Structural Analysis" A. K. Ghosh, P. R. Nyalapatla, S. Kovela, K. V. Rao, M. Brindisi, H. L. Osswald, M. Amano, M. Aoki, J. Agniswamy, Y.-F. Wang, I. T. Weber, H. Mitsuya J. Med. Chem. 201861, 4561-4577. 

327. "(Bicyclo[2.2.1]hepta-2,5-diene)[(2S,3S)-bis(diphenylphosphino)butane]rhodium Perchlorate" A. K. Ghosh, J. N. Williams eROS2018, ASAP.

326"Determination of absolute configuration and binding efficacy of benzimidazole-based FabI inhibitors through the support of electronic circular dichroism and MM-GBSA techniques" J. Ren, T. L. Mistry, P.-C. Su, S. Mehboob, R. Demissie, L. W.-M. Fung, A. K. Ghosh, M. E. Johnson Bioorg. & Med. Chem. Lett. 201828, 2074-2079.

325. “The Curtius Rearrangement: Mechanistic Insight and Applications in Natural Product Syntheses” A. K. Ghosh., A. Sarkar, M. Brindisi. Org. & Biomol. Chem. 2018, 16, 2006-2027.

324. “Design of Highly Potent, Dual Acting and Central Nervous System Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants” A. K. Ghosh; K. V. Rao, P. R. Nyalapatla, S. Kovela, M. Brindisi, H. L. Osswald, B. S. Reddy, J. Agniswamy, Y.-F. Wang, M. Aoki, S.-i. Hattori, I. T. Weber, H. MitsuyaChemMedChem 2018, 13, 803-815. 

323. "Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once it Occurs, It Predisposes HIV-1 to Develop DRV Resistance” M. Aoki, D. Das, H. Hayashi, H. Aoki-Ogata, Y. Takamatsu, A. K. Ghosh, H. Mitsuya mBio, 2018, 9, e02425-17. 

322. "GRL-079, a novel  HIV-1 protease inhibitor, is extremely potent against multi-drug-resistant HIV-1 variants and has a high genetic barrier against the emergence of resistant variants" N. S. Delino, M. Aoki, H. Hayashi, S.-i. Hattori, S. B. Chang, Y. Takamatsu, C. D. Martyr, D. Das, A. K. Ghosh, H. Mitsuya Antimicrob. Agents Chemother. 2018, 62, e02060-17.

321. Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester A. K. Ghosh, A. K. Ghosh, G. C. Reddy, A. J. MacRae, M. S. Jurica Org. Lett.201820, 96-99.

 

2017

320. “Design, synthesis, biological evaluation, and X-ray studies of HIV-1 protease inhibitors with modified P2'-ligands of Darunavir” A. K. Ghosh, W. S. Fyvie, M. Brindisi, M. Steffey, J. Agniswamy, Y.-F. Wang, M. Aoki, M. Amano, I. T. Weber, H. Mitsuya ChemMedChem, 2017, 12, 1942-1952.

319. “A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency” M. Aoki, H. Hayashi, K. V. Rao, D. Das, N. Higashi-Kuwata, H. Bulut, H. Aoki-Ogata, Y. Takamatsu, R. S. Yedidi, D. A. Davis, S.-i. Hattori, N. Nishida, K. Hasegawa, N. Takamune, P. R. Nyalapatla, H. L. Osswald, H. Jono, H. Saito, R. Yarchoan, S. Misumi, A. K. Ghosh, H. Mitsuya eLife, 2017, 6:e28020. DOI: https://doi.org/10.7554/eLife.28020

318. “GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane-Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro” M. Amano, P. M. Salcedo-Gomez, R. S. Yedidi, N. S. Delino, H. Nakata, K. V. Rao, A. K. Ghosh, H. Mitsuya Scientific Reports 2017, 7, 12235.

317. "Highly Stereoselective Asymmetric Aldol Routes to tert-Butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building Blocks for Novel Protease Inhibitors.” A. K. Ghosh, E. L. Cárdenas, M. Brindisi Tetrahedron Letters 2017, 58, 4062-4065.

316. “Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1’-P2’ ligands” A. K. Ghosh, W. S. Fyvie, M. Brindisi, M. Steffey, J. Agniswamy, Y.-F. Wang, M. Aoki, M. Amano, I. T. Weber, H. Mitsuya Bioorg. & Med. Chem. Lett. 2017, 27, 4925-4931.

315. "An enantioselective enzymatic desymmetrization route to hexahydro-4H-furopyranol, a high-affinity ligand for HIV-1 protease inhibitors" A. K. Ghosh, A. Sarkar Tetrahedron Letters 2017, 58, 3230-3233.

314. "Lewis Acid Mediated Cyclizations: Diastereoselective Synthesis of Six- to Eight-Membered Substituted Cyclic Ethers" A. K. Ghosh, A. J. Tomaine, K. E. Cantwell Synthesis 2017, 14, 4229-4246.

313. "Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-like Oxotricyclic Core as the P2-Ligand to Combat Multidrug-Resistant HIV Variants" A. K. Ghosh, K. V. Rao, P. R. Nyalapatla, H. L. Osswald, C. D. Martyr, M. Aoki, H. Hayashi, J. Agniswamy, Y.-F. Wang, H. Bulut, D. Das, I. T. Weber, H. Mitsuya J. Med. Chem. 2017, 60, 4267-4278.

312. "Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex" A. K. Ghosh, M. Brindisi, P. R. Nyalapatla, J. Takayama, J.-R. Ella-Menye, S. Yashchuk, J. Agniswamy, Y.-F. Wang, M. Aoki, M. Amano, I. T. Weber, H. Mitsuya, Bioorg. & Med. Chem. 2017, 25, 5114-5127.

311. "Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands" A. K. Ghosh, M. Brindisi, Y.-C. Yen, Em. L. Cardenas, J.-R. Ella-Menye, N. Kumaragurubaran, X. Huang, J. Tang, A. D. Mesecar, Bioorg. & Med. Chem. Lett., 2017, 27, 2432-2438.

310. "HIV-Associated Neurocognitive Disorder (HAND) and the Prospect of Brain-Penetrating Protease Inhibitors for Antiretroviral Treatment" A. K. Ghosh, A. Sarkar, H. Mitsuya, Med. Res. Arch., 2017, 5.

309. "Total Syntheses of both enantiomers of amphirionin 4: A chemoenzymatic based strategy for functionalized tetrahydrofurans" A. K. Ghosh, P. R. Nyalapatla, Tetrahedron, 2017, 73, 1820-1830.

308. "A fission yeast cell-based system for multidrug resistant HIV-1 proteases." Z. Benko, D. Liang, G. Li, R. T. Elder, A. Sarkar, J. Takayama, A. K. Ghosh, R. Y. Zhao, Cell & Bioscience, 2017, 7:5.

 

 

 



Complete Collection: 1980 - 2016

307. "Benzimidazole-based FabI inhibitors: A promising novel scaffold for anti-staphylococcal drug" T. L. Mistry, L. Truong, A. K. Ghosh, M. E. Johnson, S. Mehboob, ACS Infectious Diseases20163, 54-61.

306. "Achmatowicz reaction and its application in the syntheses of bioactive molecules" A. K. Ghosh, M. Brindisi, RSC Advances2016, 6, 111564-11159.

305. "Enantioselective total synthesis and structural assignment of callyspongiolide" A. K. Ghosh, L. A. Kassekert, J. D. Bungard, Org. and Biomol. Chem. 2016, 14, 11357-11370.

304. "Enantioselective Syntheses of (-)-Alloyohimbane and (-)-Yohimbane by an Efficient Enzymatic Desymmetrization Process" A. K. Ghosh, A. Sarkar, Eur. J. Org. Chem. 2016, 36, 6001-6009.

303. "The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer's Disease" A. K. Ghosh, E. L. Cardenas, H. L. Osswald, Top. Med. Chem., 2016, 1-59.

302. M. R. Sivik, A. K. Ghosh, A. Sarkar, “Cesium Carbonate” (2016), Encyclopedia of Reagents for Organic Synthesis [Online], John Wiley & Sons Ltd., http://onlinelibrary.wiley.com/book/10.1002/047084289X [5 Dec 2016]

301. "A Modified P1 Moiety Enhances Antiviral Activity against Various Multi-Drug-Resistant HIV-1 Variants and Central Nervous System Penetration of a Novel Nonpeptidic, Protease Inhibitor, GRL-10413, In Vitro" M. Amano, P. Salcedo-Gómez, R. Zhao, R. Yedidi, D. Das, H. Bulut, N. Delino, S. Reddy, A. K. Ghosh, H. Mitsuya, Antimicrob. Agents Chemother. 2016, 60, 7046-7059.

300. "Anharmonic Modeling of the Conformation-specific IR Spectra of Ethyl, n-propyl, and n-butylbenzene" D. P. Tapor, D. M. Hewett, S. Bocklitz, J. A. Korn, A. J. Tomaine, A. K. Ghosh, T. S. Zwier, E. L. Sibert III J. Chem. Phys. 2016, 144, 224310.

299. "Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structure Studies, and Biological Evaluation" A. K. Ghosh, H. L. Osswald, K. Glauninger, J. Agniswamy, Y. F. Wang, H. Hayashi, M. Aoki, I. T. Weber, H. Mistuya, J. Med. Chem., 2016, 6826-6837.

298. "Enantioselective Synthesis of Both Epimers at C-21 in the Proposed Structure of Cytotoxic Macrolide Callyspongiolide” A. K. Ghosh, L. A. Kassekert, Org. Lett. 2016, 18, 3274-3277.

297. "Design, Synthesis and in Vitro Splicing Inhibition of Desmethyl and Carba-Derivatives of Herboxidiene" A. K. Ghosh, K. Lv, N. Ma, E. L. Cardenas, K. A. Effenberger, M. S. Jurica. Organic & Biomolecular Chemistry 2016, 14, 5263-5271.

296. "An enantioselective synthesis of the C3–C21 segment of the macrolide immunosuppressive agent FR252921” A. K. Ghosh and S. Rodriguez. Tetrahedron Letters 2016, 57, 2884-2887.

295. "Enantioselective Total Synthesis of (+)-Amphirionin-4" A. K. Ghosh and P. R. Nyalapatla. Org. Lett. 2016, 18, 2296-2299.

294. "Defining Viral DRiPs: Immunosurveillance Generates a Common Peptide From Different Influenza Virus Reading Frames" N. Yang, J. S. Gibbs, H. S. Hickman, G. V. Reynoso, A. K. Ghosh, J. R. Bennink, J. W. Yewdell. J. Immun. 2016, 196, 3608-3617.

293. "C-5-Modified Tetrahydropyrano-Tetrahydrofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir" M. Aoki, H. Hayashi, R. S. Yedidi, C. D. Martyr, Y. Takamatsu, H. Aoki-Agata, T. Nakamura, H. Nakata, D. Das, Y. Yamagata, A. K. Ghosh, H. Mitsuya. J. Virol. 2016, 90, 2180-2194.

292. "Design of potent and highly selective inhibitors for human β-secretase 2 (memaspin 1), a target for type 2 diabetes" A. K. Ghosh, B. S. Reddy, Y.-C. Yen, E. L. Cardenas, K. V. Rao, D. Downs, X. Huang, J. Tang, A. D. Mesecar. Chemical Science, 2016, 7, 3117-3122.

291. "Stereoselective Synthesis of Substituted Oxocene Cores by Lewis Acid Promoted Cyclization" A. K. Ghosh, A. J. Tomaine, K. E. Cantwell. Org. Lett. 2016, 18, 396-399.

290. "Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS" A. K. Ghosh, H. L. Osswald, G. Prato. J. Med. Chem. 2016, 59, 5172-5208.

289. "Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages" K. A. Effenberger, V. K. Urabe, B. E. Prichard, M. S. Jurica, A. K. Ghosh. RNA, 2016, 22, 350-359. PMID: 26742993

288. “Design, Synthesis, Biological Evaluation and X-ray Structural Studies of HIV-1 Protease Inhibitors Containing Substituted Fused-Tetrahydropyranyl Tetrahydrofuran as P2-Ligands” A. K. Ghosh, C. D. Martyr, L. A. Kassekert, P. R. Nyalapatla, M. Steffey, J. Agniswamy, Y.-F. Wang, I. T. Weber, H. Mitsuya. Org. & Bio Chem. 2015, 13, 11607-11621. PMID: 26462551

287. “X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: structural implications for drug design” S. E. St. John, M. D. Therkelsen, P. R. Nyalapatla, H. L. Osswald, A. K. Ghosh, A. D. Mesecar. Bioorg. Med. Chem. Lett. 2015, 25, 5072-5077. PMID: 26592814

286. “Design of HIV-1 Protease Inhibitors with Amino-bis-Tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation and Protein-Ligand X-ray Studies” A. K. Ghosh, C. D. Martyr, H. L. Osswald, V. R. Sheri, L. A. Kassekert, S. Chen., J. Agniswamy, Y.-F. Wang, H. Hayashi, M. Aoki, I. T. Weber, H. Mitsuya. J. Med. Chem. 2015, 58, 6994-7006.PMID: 26306007

285. “Prospects of β-Secretase Inhibitors for the Treatment of Alzheimer’s Disease” A. K. Ghosh, J. Tang. ChemMedChem, 2015, 10, 1463-1466. PMID: 26140607

284. “Structure-based Design of Potent HIV-1 Protease Inhibitors with Modified P1-Biphenyl Ligands: Synthesis, Biological Evaluation, and Enzyme-inhibitor X-ray Structural studies" A. K. Ghosh, X. Yu, H. L. Osswald, J. Agniswamy, Y-F. Wang, M. Amano, I. T. Weber, H. Mitsuya. J. Med. Chem. 2015, 58, 5334-5343. PMID: 26107245

283. “Ligand-induced dimerization of MERS coronavirus nsp5 protease (3CLpro): implications for nsp5regulation and the development of antivirals” S. Tomar, M. L. Johnston, S. E. St. John, H. L. Osswald, P. R. Nyalapatla, L. N. Paul, A. K. Ghosh, M. R. Denison, A. D. Mesecar. J. Biol. Chem. 2015, 290, 19403-19422. PMID: 26055715

282. “Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation” R. Jossé, Y-W. Zhang, V. Giroux, A. K. Ghosh, J. Luo , Y. Pommier. Mar. Drugs 2015, 13, 3625-3639. PMID: 26058013

281. “Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20” J. Agniswamy, J. M. Louis, C-H. Shen, S. Yashchuk, A. K. Ghosh, I. T.Weber. J. Med. Chem. 2015, 58, 5088-5095. PMID: 26010498

280. “Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands” A. K. Ghosh, J. Takayama, L. Kassekert, J-R. Ella-Menye, S. Yashchuk, J. Agniswamy, Y-F. Wang, M. Aoki, M. Amano, I. Weber, H. Mitsuya. Bioorg. Med. Chem. Lett. 2015, 25, 4903-4909. PMID: 26096678

279. "Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV" H. Lee, H. Lei, B.D. Santarsiero, J.L. Gatuz, S. Cao, A.J. Rice, K. Patel, M.Z. Szypulinski, I. Ojeda, A.K. Ghosh, M.E. Johnson. ACS Chemical Biology, 2015, 59, 2625-2635. PMID: 25691652

278. "A Novel Tricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor, GRL-0739, Effectively Inhibits the Replication of Multi-Drug-Resistant HIV-1 Variants and Has a Desirable Central Nervous System (CNS) Penetration Property In Vitro" M. Amano, Y. Tojo, P.M. Salcedo-Gomez, G.I. Parham, P. Nyalapatla, D. Das, A.K. Ghosh, H. Mitsuya. Antimicrob Agents Chemother. 2015, 59, 1895-1904. PMID: 25583709.

277. "Insights into the Mechanism of Inhibition of CXCR4: Identification of Piperidinylethanamine Analogs as Anti-HIV Inhibitors" D. Das, K. Maeda, Y. Hayashi, N. Gavande, D. V. Desai, S. B. Chang, A. K. Ghosh, H. Mitsuya. Antimicrob. Agents Chemother, 2015, 58, 2895-2940. PMID: 25565044

276. “Organic Carbamates in Drug Design and Medicinal Chemistry" A. K. Ghosh and M. Brindisi. J. Med. Chem. 2015, 56, 3314-3317. PMID: 26185337.

275. “Enantioselective Synthesis of Dioxatriquinane Structural Motifs for HIV-1 Protease Inhibitors Using a Cascade Radical Cyclization” A. K. Ghosh; C-X. Xu; H. L. Osswald. Tetrahedron Lett. 2015, 25, 1292-1296. PMID: 25677657.

274. “Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI)” S. Mehboob, J. Songs, K. E. Hevner, P-C. Su, T. Boci, L. Brubaker, L. Truong, T. Mistry, J. Deng, J. L. Cook, B. D. Santarsiero, A. K. Ghosh, M. E. Johnson, Bioorg. Med. Chem. Lett. 2015, 25, 1292-1296. PMID: 25677657

273. “Structure-based design, synthesis and biological evaluation of novel beta-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand” A. K. Ghosh, M. Brindisi, Y-C, Yen, X. Xu, X. Huang, T. Devasamudram, G. Bilcer, H. Lei, G. Koelsch, A. D. Mesecar, J. Tang. Bioorg. Med. Chem. Lett. 2015, 25, 668-672.

272. “Design of Gem-difluoro-bis-Tetrahydrofuran as P2-Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation” A. K. Ghosh, S. Yashchuk, A. Mizuno, N. Chakraborty, J. Agniswamy,Y.-F. Wang, M. Aoki, P. M. Salcedo Gomez, M. Amano, I. T. Weber, H. Mitsuya. ChemMedChem 2015, 10, 107-115.

271. "Characterization of a Drosophila Ortholog of the Cdc7 Kinase: A Role for Cdc7 in Endoreplication Independent of Chiffon" R. Stephenson; M. R. Hosler; N. S. Gavande; A. K. Ghosh; V. M. Weake. J. Biol. Chem. 2015, 290, 1332-1347. PMID: 25451925.

270. "Structure-based Design of Drugs and Other Bioactive Molecules- Tools and Strategies" A. K. Ghosh and S. Gemma, Wiley-VCH, 2014, 475 pp.

269. "Enantioselective Synthesis of Spliceostatin E and Evaluation of Biological Activity" A. K. Ghosh, A. M. Veitschegger, V. R. Sheri, K. A. Effenberger, M. S. Jurrica. Organic Letters 2014, 16, 6200-6203.

268. “Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.” H. Hayashi, N. Takamune, T. Nirasawa, M. Aoki, Y. Morishita, D. Das, Y. Koh, A. K. Ghosh, S. Misumi, H. Mitsuya. Proc. Natl. Acad. Sci. USA, 2014, 79, 5697-5709.

267. “An enantioselective synthesis of a MEM-protected aetheramide A derivative” A. K. Ghosh, K. V. Rao, S. Akasapu. Tetrahedron Lett. 2014, 55, 5191-5194.

266. “A convergent synthesis of carbocyclic sinefungin and its C5 epimer” A. K. Ghosh, Kai Lv Eur. J. Org. Chem. 2014, 6761-6768.

265. “Coronaviruses Resistant to a 3C-like Protease Inhibitor Are Attenuated for Replication and Pathogenesis Revealing a Low Genetic Barrier but High Fitness Cost of Resistance” Xufang Deng, Sarah E. St. John, Heather L. Osswald, Amornrat O’Brien, Bridget S. Banach, Katrina Sleeman, Arun K. Ghosh, Andrew D. Mesecar, and Susan C. Baker. J. Virol. 2014, 88, 11886-11898.

264. “Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands." A. K. Ghosh, G. E. Schiltz, L. N. Rusere, H. L. Osswald, D. E. Walters, M. Amano, H. Mitsuya. Org. Biomol. Chem. 2014, 12, 6842–6854.

263. “FeCl3-catalyzed tandem Prins and Friedel–Crafts cyclization: a highly diastereoselective route to polycyclic ring structures” A. K. Ghosh, C, Keyes, A. M. Veitschegger. Tetrahedron Lett. 2014, 55, 4251–4254.

262. “Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives” A. K. Ghosh, Z.-H, Chen, K. A. Effenberger, M. S. Jurica. J. Org. Chem. 2014, 79, 5697–5709.

261. “Total Synthesis of GEX1Q1, Assignment of C5 Stereoconfiguration and Evaluation of Spliceosome Inhibitory Activity” A. K. Ghosh, N. Ma, K. A. Effenberger, M. S. Jurica Org. Lett. 2014, 16, 3154–3157.

260. “Metabolism-directed structure optimization of benzimidazole-based Francisella tularensis enoyl-reductase (FabI) inhibitors.” Y.-Y. Zhang; Y. Liu; S. Mehboob; J.-H. Song; T. Boci; M. E. Johnson; A. K. Ghosh; H. Jeong. Xenobiotica 2014, 44, 404-416.

259. “Conserved hydrogen-bonding network of P2 bis-tetrahydrofuran containing HIV-1 protease inhibitors (PI) with protease active site amino acid-backbone aid in their activity against PI-resistant HIV.” R. S. Yedidi; H. Garimella; M. Aoki; H. Aoki; D. V. Desai; S. B. Chang; D. A. Davis; W. S. Fyvie; J. D. Kaufman; D. W. Smith; D. Das; P. T. Wingfield; K. Maeda; A. K. Ghosh; H. Mitsuya. Antimicrob. Agents Chemother. 2014, 58, 3679-3688.

258. “An intramolecular cascade cyclization of 2-aryl indoles: efficient methods for the construction of 2,3-functionalized indolines and 3-indolinones.” A. K. Ghosh; Z.-H, Chen. Org. Biomol. Chem. 2014, 12, 357-3571.

257. “A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant.” S. Agnihothram; B. L. Yount, Jr.; E. F. Donaldson; J. Huynh; V. D. Menachery; L. E. Gralinski; R. L. Graham; M. M. Becker; S. Tomar; T. D. Scobey; H. L. Osswald; A. Whitmore; R. Gopal; A. K. Ghosh; A. Mesecar; M. Zambon; M. Heise; M. R. Denison; R. S. Baric. mBio 2014, 5, e00047- e00014.

256. “Coherence between Cellular Responses and in Vitro Splicing Inhibition for the Anti-tumor Drug Pladienolide B and Its Analogs,” K. A. Effenberger; D. D. Anderson; W. M. Bray; B. E. Prichard; N. Ma; M. S. Adams; A. K. Ghosh; M. S. Jurica. J. Biol. Chem. 2014, 289, 1938-1947.

255. “BACE1 inhibitors (β-secretase) for the treatment of Alzheimer's Disease” A. K. Ghosh and H. L. Osswald. Chem. Soc. Rev. 2014, 43, 6765-6813.

254. “Platensimycin and Platencin” A. K. Ghosh and K. Xi. In Natural Products in Medicinal Chemistry, edited by Stephen Hanessian. 2014, p-271-300.

253. “GRL-04810 and GRL-05010, Difluoride-Containing Nonpeptidic HIV-1 Protease Inhibitors (PIs) That Inhibit the Replication of Multi-PI-Resistant HIV-1 In Vitro and Possess Favorable Lipophilicity That May Allow Blood-Brain Barrier Penetration.” P. M. Salcedo Gomez, M. Amano, S. Yashchuk, A. Mizuno, D. Das, A. K. Ghosh, Mitsuya, H. Antimicrob. Agents Chemother. 2013, 57, 6110-6121.

252. “Enantioselective Total Synthesis of Macrolide (+)-Neopeltolide” A. K. Ghosh, K. Shurrush, Z. Dawson. Org. Bimol. Chem. 2013, 11, 7768-7777.

251. "Enantioselective Syntheses of FR901464 and Spliceostatin A: Potent Inhibitors of Spliceosome” A. K. Ghosh, Z. Chen. Org. Lett. 2013, 5088-5091.

250. “S-Adenosyl-Homocysteine Is a Weakly Bound Inhibitor for a Flaviviral Methyltransferase” H. Chen, B. Zhou, M. Brecher, N. Banavali, S. A. Jones, Z. Li, J. Zhang, D. Nag, L. D. Kramer, A. K. Ghosh, H.Li, PLoS ONE 2013, 8, e76900, 1-12.

249. “Metabolism-Directed Structure Optimization of Benzimidazole-Based Francisella tularensis Enoyl-Reductase (FabI) Inhibitors” Y.-Y. Zhang, S. Mehboob, J.-H. Song, T. Boci, M. E. Johnson, H. Jeong, A.K. Ghosh. Xenobiotica, 2013, 1-13.ii

248. “The Structural Evolution of β-Secretase Inhibitors: A Focus on the Development of Small-Molecule Inhibitors” S. Butini, S. Brogi, E. Novellino, G. Campiani, A. K. Ghosh, M. Brindisi, S. Gemma. Curr. Top. Med. Chem., 2013, 13, 1787-1807.

247. “Highly Potent HIV-1 Protease Inhibitors with Novel Tricyclic P2-ligands: Design, Synthesis, and Protein-ligand X-Ray Studies” A. K. Ghosh, G. L. Parham, C. D. Martyr, P. R. Nyalapatla, H. L. Osswald, J. Agniswamy, Y.-F. Wang, M. Amano, I. T. Weber, H. Mitsuya. J. Med. Chem., 2013, 56, 6792–6802.

246. “P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety" R. S. Yedidi, K. Maeda, W. S. Fyvie, M. Steffey, D. A. Davis, I. Palmer, M. Aoki, J. D. Kauffman, S. J. Stahl, H. Garimella, D. Das, P. T. Wingfield, A. K. Ghosh, H. Mitsuya Kovalevsky. Antimicrob. Agents Chemother. 2013, 57, 4920-4927.

245. “Joint X-ray/Neutron Crystallographic Study of HIV-1 Protease with Clinical Inhibitor Amprenavir: Insights for Drug Design.” I. T. Weber, M. J. Waltman, M. Mustyakimov, M. P. Blakeley, D. A. Keen, A. K. Ghosh, P. Langan, A. Y. Kovalevsky. J. Med. Chem., 2013, 56, 5631-5635.

244. “Synergistic Inhibitor Binding to the Papain-Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications” H. Lee, S. Cao, K. E. Hevener, L. Truong, J. L. Gatuz, K. Patel, A. K. Ghosh, M. E. Johnson. Chem. Med. Chem. 2013, 8, 1361-1372.

243. “Anti-HIV Protease Inhibitor Darunavir” A. K. Ghosh and B. D. Chapsal. In Introduction to Biopharmaceuticals and Small Molecule Drug Research and Development: theory and case studies. Edited by Robin Ganellin, Roy Jefferis and Stan Roberts. Elsevier 2013, Chapter 13, 355-384.

242. “Bifunctional Cinchona Alkaloid-Squaramide-Catalyzed Highly Enantioselective aza-Michael Addition of Indolines to α, β-Unsaturated Ketones” A. K. Ghosh and B. Zhou. Tetrahedron Lett. 2013, 54, 3500-3502.

241. “Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1-pyrrolidinone or P2-tris-THF." J. Agniswamy, C. Shen, Y-F. Wang, A. K. Ghosh, K. V. Rao, C.-X. Xu, J. M. Sayer, J. M. Louis, and I. T. Weber. J. Med. Chem. 2013 , 56, 4017-4027.

240. “Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism” H. Wu, D. Downs, K. Ghosh, A. K. Ghosh, P. Staib, M. Monod and J. Tang. FASEB Journal, 2013, 27, 2132-2144.

239. “Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs” H. Chen, L. Liu, S. A. Jones, N. Banavali, J. Kass, Z. Li, J. Zhang, L. D. Kramer, A. K. Ghosh and H. Li. Antiviral Research 2013, 97, 232-239.

238. "Novel P2 Tris-tetrahydrofuran Group in Antiviral Compound 1 (GRL-0519) Fills the S2 Binding Pocket of Selected Mutants of HIV-1 Protease” H. Zhang, Y-F. Wang; C-H. Shen, J. Agniswamy, K. V. Rao, C. X. Xu, A. K. Ghosh, R. W. Harrison and I. T. Weber. J. Med. Chem. 2013 , 56 , 1074-1083.

237. “Enantioselective Synthesis of Spiro [cyclohexane-1,3-indolin]-2¢-ones Containing Multiple Stereocenters via Organocatalytic Michael/Aldol Cascade Reactions” A. K. Ghosh and B. Zhou. Tetrahedron Lett. 2013, 54. 2311-2314.

236. “GRL-0519, A Novel Oxatricyclic-Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses the Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro” M. Amano, Y. Tojo, P. M. Salcedo-Gomez, J. R. Campbell, D. Das, M. Aoki, C-X. Xu, K. V. Rao, A. K. Ghosh and H. Mitsuya. Antimicrobial Agents and Chemotherapy 2013, 57, 2036-2046 .

235. "Enantioselective Total Synthesis of (+)-Lithospermic Acid " A. K. Ghosh, X. Cheng and B. Zhou. Org. Lett. 2012, 14, 5046-5049.

234. "Enantioselective Total Synthesis of Pladienolide B: A Potent Spliceosome Inhibitor" A. K. Ghosh and D. D. Anderson. Org. Lett. 2012, 14, 4730-4733.

233. "Structure-Based Design of Highly Selective Beta-Secretase Inhibitors: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Crystal Structure" A. K. Ghosh, K. V. Rao, N. D. Yadav, D. D. Anderson, N. Gavande, X. Huang, S. Terzyan, and J. Tang. J. Med. Chem., 2012, 55, 9195-9207.

232. "Lasonolide A, a potent and reversible inducer of chromosome condensation” Y-W Zhang, A. K. Ghosh, Y. Pommier, Cell Cycle 2012, 11, 4424-4435.

231. “Structure-based Design, Synthesis and Biological Evaluation of Dihydroquinazoline-Derived Potent b-Secretase Inhibitors” A. K. Ghosh, S. Pandey, S. Gangarajula, S. Kulkarni, D. D. Anderson, N. S Gavande, X. Xu, X. Huang, and J. Tang. Bioorg. Med. Chem. Lett. 2012, 22, 5460-5465.

230. "Diastereoselective Synthesis of Substituted Tetrahydropyrans by Cu(II)-Bisphosphine Catalyzed Olefin Migration and Prins Cyclization", A. K. Ghosh, J. Kass, D. R. Nicponski, and C. Keyes. Synthesis. 2012, 44, 3579-3589.

229. "Total Synthesis of Potent Antitumor Macrolide (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy” A. K. Ghosh, X. Cheng, R. Bai, E. Hamel. Eur. J. Org. Chem. 2012, 4130-4139.

228. "Synthesis of Functionalized 4-Methylenetetrahydropyrans by Oxidative Activation of Cinnamyl or Benzyl Ethers" A. K. Ghosh and X. Cheng. Tetrahedron Lett. 2012, 53, 2568-2570.

227. "TiCl4-Promoted Tandem Carbonyl or Imine Addition and Friedel-Crafts Cyclization: Synthesis of Benzo-fused Oxabicyclooctanes and Nonanes" A. K. Ghosh, C. D. Martyr, C.-X. Xu. Org. Lett. 2012, 14, 2002-2005.

226. “Potent Antiviral HIV-1 Protease Inhibitor GRL-02031 Adapts to the Structures of Drug Resistant Mutants with Its P1 ¢-Pyrrolidinone Ring” Y-C. E. Chang, X-X. Yu, Y. Zhang, Y. Tie, Y.-F. Wang, S. Yashcuk, A. K. Ghosh, R. W. Harrison, I. T. Weber. J. Med. Chem. 2012, 55, 3387-3397.

225. "Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group” F. Li, I. Chvyrkova, S. Terzyan, N. Wakeham, R. Turner, A. K. Ghosh, X. C. Zhang, J. Tang. Appl. Microbiol. Biotechnol. 2012, 94, 1041-1049.

224. "A Tandem Olefin Migration and Prins Cyclization using Cu(OTf)2-Bisphosphine Complexes: An Improved Synthesis of Functionalized Tetrahydropyrans" A. K. Ghosh, D. R. Nicponski, J. Kass. Tetrahedron Lett. 2012, 53, 3699-3702.

223. “Stereoselective Synthesis of Both Tetrahydropyran Rings of the Antitumor Macrolide, (-)-Lasonolide A” A. K. Ghosh and G.-B. Ren. J. Org. Chem. 2012, 77, 2559-2565.

222. “Substituent effects on P2-Cyclopentyltetrahydrofuranyl Urethanes: Design, Synthesis, and X-ray studies of potent HIV-1 Protease Inhibitors” A. K. Ghosh, B. D. Chapsal, M. Steffey, J. Agniswamy, Y.-F. Wang, M. Amano, I. T. Weber, H. Mitsuya. Bioorg. Med. Chem. Lett. 2012, 22, 2308-2311.

221. “Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors” Y. Tie, P. Boross, Y.-F. Wang, T.-Y. Chiu, A. K. Ghosh, J. Tozser, R. Harrison, I. Weber. Protein Science, 2012, 21, 339-350.

220. "A Stereoselective Synthesis of (-)-Viridiofungin A Utilizing a TiCl4-Promoted Asymmetric Multicomponent Reaction” A. K. Ghosh and J. Kass. Organic Letters 2012, 14, 510-512.

219. "Developing β-secretase inhibitors for treatment of Alzheimer’s disease” A. K. Ghosh, M. Brindisi and J. Tang. J. Neurochem. 2012, 120, 71-83.

218. "Enhancing Protein Backbone Binding - A Fruitful Concept for Combating Drug-Resistant HIV” A. K. Ghosh, D. D. Anderson, I. T. Weber H. Mitsuya. Angew. Chem. Int. Ed. 2012, 51, 1778-1802.

217. "Cu(II)-Catalyzed Olefin Migration and Prins Cyclization: Highly Diastereoselective Synthesis of Substituted Tetrahydropyrans” A. K. Ghosh and D. R. Nicponski. Organic Letters, 2011, 13, 4328-4331.

216. "Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethane as P2-Ligands: Synthesis, Biological Evaluations, and Protein-Ligand X-ray Crystal Structure” A. K. Ghosh, B. D. Chapsal, G. L. Parham, M. Steffey, J. Agniswamy, Y.-F. Wang, M. Amano, I. T. Weber, H. Mitsuya. J. Med. Chem. 2011, 54, 5890-5901.

215. "Tetrahydrofuran and related heterocyclic derivatives as HIV protease inhibitors” A. K. Ghosh and D. D. Anderson. Future Med. Chem. 2011, 3, 1181-1197.

214. "The Loss of Darunavir’s Protease Dimerization Inhibition Activity Is Associated with HIV-1 Acquisition of Resistance to Darunavir” Y. Koh, M. Aoki, M. L. Danish, H. Aoki-Ogata, M. Amano, D. Das, R. W. Shafer, A. K. Ghosh, H. Mitsuya. J. Virology, 2011, 85, 10079-10089.

213. "Enantioselective Total Synthesis of (-)-Zampanolide, a Potent Microtubule-Stabilizing Agent" A. K. Ghosh and X. Cheng Organic Letters 2011, 13, 4108-4111.

212. "Treating transgenic Alzheimer mice with a β-secretase inhibitor, what have we learned?” J. Tang and A. K. Ghosh. Aging 2011, 3, 14-16.

211. "Design, Synthesis, and X-ray Structure of Substituted Bis-tetrahydrofuran (Bis-THF)-Derived Potent HIV-1 Protease Inhibitors" A. K. Ghosh, C. D. Martyr, M. Steffey, Y.-F. Wang, J. Agniswamy, M. Amano, I. T. Weber and H. Mitsuya. ACS Medicinal Chemistry Letters 2011, 2, 298–302.

210. "Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants" K. Ide, M. Aoki, M. Amano, Y. Koh, R. S. Yedidi, D. Das, S. Leschenko, B. Chapsal, A. K. Ghosh and H. Mitsuya. Antimicrob. Agents Chemother. 2011, 55, 1717-1727.

209. "Design and Synthesis of Potent HIV-1 Protease Inhibitors Incorporating Hexahydrofuropyranol-Derived High Affinity P2 Ligands: Structure−Activity Studies and Biological Evaluation" A. K. Ghosh, B. D. Chapsal, A. Baldridge, M. P. Steffey, D. E. Walters, Y. Koh, M. Amano and H. Mitsuya. J. Med. Chem. 2011, 54, 622-634.

208. "Beta-Secretase Inhibitor GRL-8234 Rescues Age-Related Cognitive Decline in APP Transgenic Mice” W.-P. Chang, X. Huang, D. Downs, J. R. Cirrito, G. Koelsch, D. M. Holtzman, A. K. Ghosh, J. Tang. FASEB J. 2011, 25, 775-784.

207. "A Stereoselective Synthesis of (+)-Herboxidiene/GEX1A" A. K. Ghosh and J. Li Org. Lett. 2011, 13, 66-69.

206. "The Assembly-Inducing Laulimalide/Peloruside A Binding Site on Tubulin: Molecular Modeling and Biochemical Studies with [3H]Peloruside A" T. L. Nguyen, X. Xu, R. Gussio, A. K. Ghosh, and E. Hamel. J. Chem. Inf. Model. 2010, 50, 2019-2028.

205. "Capturing the Essence of Organic Synthesis: From Bioactive Natural Products to Designed Molecules in Today’s Medicine" A. K. Ghosh. J. Org. Chem. 2010, 75, 7967-7989.

204. "Probing Multidrug-Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors" A. K. Ghosh, C.-X. Xu, K. V. Rao, A. Baldridge, J. Agniswamy, Y.-F. Wang, I. T. Weber, M. Aoki, S. G. P. Miguel, M. Amano, and H. Mitsuya. ChemMedChem 2010, 5, 1850-1854.

203. "In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors" Y. Koh, M. Amano, T. Towata, M. Danish, S. Leshchenko-Yashchuk, D. Das, M. Nakayama, Y. Tojo, A. K. Ghosh, and H. Mitsuya. J. Virol. 2010, 84, 11961-11969.

202. "The Discovery of b-Secretase and Development Toward a Clinical Inhibitor for AD: An Exciting Academic Collaboration” J. Tang, L. Hong, A. K. Ghosh in Aspartic Acid Proteases as Therapeutic Targets, Edited by A. K. Ghosh, Vol. 45, 2010, 413-438.

201. "Development of HIV-1 Protease Inhibitors, Antiretroviral Resistance, and Current Challenges of HIV/AIDS Management” H. Mitsuya, A. K. Ghosh in Aspartic Acid Proteases as Therapeutic Targets, Edited by A. K. Ghosh, Vol. 45, 2010, 245-259.

200. "Darunavir, a New PI with Dual Mechanism: From a Novel Drug Design Concept to New Hope Against Drug-Resistant HIV” A. K. Ghosh, B. D. Chapsal, H. Mitsuya in Aspartic Acid Proteases as Therapeutic Targets, Edited by A. K. Ghosh, Vol. 45, 2010, 205-235.

199. "Second-Generation Approved HIV Protease Inhibitors for the Treatment of HIV/AIDS” A. K. Ghosh, B. D. Chapsal in Aspartic Acid Proteases as Therapeutic Targets, Edited by A. K. Ghosh, Vol. 45, 2010, 169-195.

198. "The FDA Approved HIV-1 Protease Inhibitors for Treatment of HIV/AIDS” A. K. Gosh, D. D. Anderson, H. Mitsuya in Burger’s Medicinal Chemistry, Drug Discovery and Development, Eds. D. J. Abraham and D. P. Rotella, Edition 7, Vol. 7, 2010, pp. 1-72.

197. "Synthesis and Biological Evaluation of New Jasplakinolide (Jaspamide) Analogs" A. K. Ghosh, Z. L. Dawson, D. K. Moon, R. Bai, and E. Hamel. Bioog. Med. Chem. Lett. 2010, 20, 5104-5107.

196. "Darunavir (Prezista): A HIV-1 Protease Inhibitor for Treatment of Multidrug-Resistant HIV" A. K. Ghosh and C. D. Martyr in Modern Drug Synthesis, Wiley, Edited by J. J. Li and D. S. Johnson, 2010, 29-44.

195. "Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions" H. Nakata , M. Kruhlak, W. Kamata, H. Ogata-Aoki, J. Li, K. Maeda, A. K. Ghosh, H. Mitsuya. Antivir. Ther. 2010, 15, 321-331.

194. "Enantioselective Syntheses of the Proposed Structures of Cytotoxic Macrolides Iriomoteolide-1a and -1b" A. K. Ghosh and H. Yuan. Org. Lett. 2010, 12, 3120–3123.

193. "Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation" A. K. Ghosh, J. Takayama, K. V. Rao, K. Ratia, R. Chaudhuri, D. C. Mulhearn, H. Lee, D. B. Nichols, S. Baliji, S. C. Baker, M. E. Johnson and A. D. Mesecar. J. Med. Chem. 2010, 53, 4968–4979.

192. "Novel Protease Inhibitors (PIs) Containing Macrocyclic Components and 3(R),3a(S),6a(R)-bis-Tetrahydrofuranylurethane (bis-THF) That Are Potent Against Multi-PI-Resistant HIV-1 Variants In Vitro" Y. Tojo, Y. Koh, M. Amano, M. Aoki, D. Das, A. K. Ghosh, and H. Mitsuya Antimicrobial Agents and Chemotherapy, 2010, 54, 3460-3470.

191. "Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases" M. A. Clementz, Z. Chen, B. S. Banach, Y. Wang, L. Sun, K. Ratia, Y. M. Baez-Santos, J. Wang, J. Takayama, A. K. Ghosh, K. Li, A. D. Mesecar, and S. C. Baker. J. Virol. 2010, 84, 4619-4629.

190. "Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction" A. K. Ghosh and J. Kass ChemComm 2010, 46, 1218-1220.

189. "Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands” A. K. Ghosh, S. Gemma, E. Simoni, A. Baldridge, D. E. Walters, K. Ide, Y. Tojo, Y. Koh, M. Amano, and H. Mitsuya Bioog. Med. Chem. Lett. 2010, 20, 1241-1246.

188. "Peloruside B, A Potent Antitumor Macrolide from the New Zealand Marine Sponge Mycale hentscheli: Isolation, Structure, Total Synthesis, and Bioactivity" A. J. Singh, C.-X. Xu, X. Xu, L. M. West, A. Wilmes, A. Chan, E. Hamel, J. H. Miller, P. T. Northcote and A. K. Ghosh. J. Org. Chem. 2010, 75, 2-10.

187. "Prediction of Potency of Protease Inhibitors Using Free Energy Simulations with Polarizable Quantum Mechanics-Based Ligand Charges and a Hybrid Water Molecule” D. Das, Y. Koh, Y. Tojo, A. K. Ghosh, and H. Mitsuya J. Chem. Info. Model, 2009, 49, 2851–2862.

186. "Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance" A. K. Ghosh, S. Kulkarni, D. D. Anderson, L. Hong, A. Baldridge, Y.-F. Wang, A. A. Chumanevich, A. Y. Kovalevsky, Y. Tojo, M. Amano, Y. Koh, J. Tang, I. T. Weber and H. Mitsuya. J. Med. Chem. 2009, 52, 7689–7705.

185. "P-Glycoprotein Mediates Efflux Transport of Darunavir in Human Intestinal Caso-2 and ABCB1 Gene-Transfected Renal LLC-PK1 Cell Lines” H. Fujimoto, M. Higuchi, H. Watanabe, Y. Koh, A. K. Ghosh, H. Mitsuya, N. Tanoue, A. Hamada and H. Saito. Biol. Pharm. Bull. 2009, 32, 1588-1593.

184. "An Asymmetric Total Synthesis of Brevisamide" A. K. Ghosh and J. Li. Org. Lett. 2009, 11, 4164–4167.

183. "Synthesis of Bioactive Natural Products by Asymmetric syn- and anti-Aldol Reactions” A. K. Ghosh and Z. L. Dawson. Synthesis, 2009, 2992-3002.

182. "Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease” A. K. Ghosh, J. Takayama, Y. Aubin, K. Ratia, R. Chaudhuri, Y. Baez, K. Sleeman, M. Coughlin, D. B. Nichols, D. C. Mulhearn, B. S. Prabhakar, S. C. Baker, M. E. Johnson and A. D. Mesecar J. Med. Chem. 2009, 52, 5228-5240.

181. "A Symmetry-Based Concise Formal Synthesis of Platencin, a Novel Lead against "Superbugs" A. K. Ghosh and K. Xi Angew. Chem. Int. Ed. 2009, 48, 5372-5375.

180. "Design of HIV-1 Protease Inhibitors with Pyrrolidinones and Oxazolidinones as Novel P1’-Ligands to Enhance Backbone-binding interactions with Protease: Synthesis, Biological Evaluation and Protein-ligand X-ray Studies” A. K. Ghosh, S. Leshchenko-Yashchuk, D. D. Anderson, A. Baldridge, M. Noetzel, H. B. Miller, Y. Tie, Y.-F. Wang, Y. Koh, I. T. Weber, and H. Mitsuya J. Med. Chem. 2009, 52, 3902-3914.

179. "Asymmetric Synthesis of anti-Aldol Segments via a Nonaldol Route: Synthetic Applications to Statines and (-)-Tetrahydrolipstatin" A. K. Ghosh, K. Shurrush, S. Kulkarni J. Org. Chem. 2009, 74, 4508-4518.

178. "A Convergent Synthesis of the Proposed Structure of Antitumor Depsipeptide, Stereocalpin A" A. K. Ghosh and C.-X. Xu Org. Lett. 2009, 11, 1963-1966.

177. “Harnessing Nature’s Insight: Design of Aspartyl Protease Inhibitors from Treatment of Drug-Resistant HIV to Alzheimer’s Disease” A. K. Ghosh J. Med. Chem. 2009, 52, 2163-2176.

176. "Stereoselective synthesis of the C1-C12 segment of iriomoteolide-1a: a very potent macrolide antitumor agent” A. K. Ghosh, H. Yuan, Tet. Lett. 2009, 50, 1416-1418.

175. "GRL-02031: A Novel Nonpeptide Protease Inhibitor (PI) Containing A Stereochemistry Defined Fused Cyclopentanyltetrahydrofuran (Cp-THF) Potent Against Multi-PI-Resistant HIV-1 In Vitro” Y. Koh, D. Das, S. Leshchenko, H. Nakata, H. Ogata-Aoki, M. Amano, M. Nakayama, A. K. Ghosh, and H. Mitsuya. Antimicrob. Agents Chemother. 2009, 53, 987-1006.

174. "Total Synthesis of (-)-Platensimycin, a Novel Antibacterial Agent” A. K. Ghosh and K. Xi. J. Org. Chem. 2009, 74, 1163-1170.

173. "A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication” K. Ratia, S. Pegan, J. Takayama, K. Sleeman, M. Coughlin, S. Baliji, R. Chaudhuri, W. Fu, B. S. Prabhakar, M. E. Johnson, S. C. Baker, A. K. Ghosh, and A. D. Mesecar, PNAS, 2008, 105, 16119-16124.

172. "L-Selectride-Mediated Highly Diastereoselective Asymmetric Reductive Aldol Reaction: Access to an Important Subunit for Bioactive Molecules” A. K. Ghosh, J. Kass, D. D. Anderson, X. Xu and C. Marian, Org. Lett. 2008, 10, 4811-4814.

171. "Solution Kinetics Measurements Suggest HIV-1 Protease Has Two Binding Sites for Darunavir and Amprenavir” A. Y. Kovalevsky, A. K. Ghosh, I. T. Weber. J. Med. Chem. 2008, 51, 6599-6603.

170. "Design and Synthesis of Stereochemically Defined Novel Spirocyclic P¬2-Ligands for HIV-1 Protease Inhibitors” A. K. Ghosh, B. D. Chapsal, A. Baldridge, K. Ide, Y. Koh, and H. Mitsuya, Org. Lett. 2008, 10, 5135-5138.

169. "Structural Evidence for Effectiveness of Darunavir and Two Related Antiviral Inhibitors against HIV-2 Protease” A. Y. Kovalevsky, J. M. Louis, A. Aniana, A. K. Ghosh, I. T. Weber J. Mol. Biol. 2008, 384, 178-192.

168. "Design, Synthesis and Antiviral Efficacy of a Series of Potent Chloropyridyl Ester-derived SARS-CoV 3CLpro Inhibitors” A. K. Ghosh, G. Gong, V. Grum-Tokars, D. C. Mulhearn, M. Coughlin, B. S. Prabhakar, K. Sleeman, S. C. Baker, M. E. Johnson, and A. D. Mesecar. Bioorg. Med. Chem. Lett. 2008, 18, 5684-5688.

167. "Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation and Protein-ligand X-ray Studies" A. K. Ghosh, S. Gemma, A. Baldridge, Y.-F. Wang, A. Y. Kovalevsky, Y. Koh, I. T. Weber, and H. Mitsuya. J. Med. Chem. 2008, 51, 6021-6033.

166. "Potent HIV-1 Protease Inhibitors Incorporating meso-Bicyclic Urethanes as P2-ligands: Structure-Based Design, Synthesis, Biological Evaluation and Protein-Ligand X-Ray Studies” A. K. Ghosh, S. Gemma, J. Takayama, A. Baldridge, S. Leshchenko-Yashchuk, H. B. Miller, Y.-F. Wang, A. Y. Kovalevsky, Y. Koh, I. T. Weber, H. Mitsuya. Org. Biomol. Chem. 2008, 6, 3703-3713.

165. "Total Synthesis of Potent Antitumor Agent (-)-Lasonolide A: a Cycloaddition-based Strategy" A. K. Ghosh and G. Gong. Chem. Asian J. 2008, 3, 1811-1823.

164. "Enantioselective Total Synthesis of (+)-Largazole, a Potent Inhibitor of Histone Deacetylase" A. K. Ghosh, S. Kulkarni. Org. Lett. 2008, 10, 3907-3909.

163. "Effect of Flap Mutations on Structure of HIV-1 Protease and Inhibition by Saquinavir and Darunavir" F. Liu, A. Y. Kovalevsky, Y. Tie, A. K. Ghosh, R. W. Harrison, I. T. Weber. J. Mol. Biol. 2008, 381, 102-115.

162. "Beta-Secretase as a Therapeutic Target for Alzheimer’s Disease” A. K. Ghosh, S. Gemma, J. Tang. Neurotherapeutics, 2008, 5, 399-408.

161. "Asymmetric multi-component reactions: convenient access to acyclic stereocenters and functionalized cyclopentenoids" A. K. Ghosh, S. S. Kulkarni, C.-X. Xu, K. Shurrush, Tet. Asy. 2008, 19, 1020-1026.

160. "Enantioselective Synthesis of Cyclopentyltetrahydrofuran (Cp-THF), an Important High-Affinity P2-Ligand for HIV-1 Protease Inhibitors” A. K. Ghosh and J. Takayama. Tet. Lett. 2008, 49, 3409-3412.

159. "Memapsin 2 (beta-secretase) inhibitors: drug development” A. K. Ghosh, N. Kumaragurubaran, L. Hong, G. Koelsh, J. Tang. Curr. Alz. Res. 2008, 5, 121-131.

158. "Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance" A. K. Ghosh, B. Chapsal, I. T. Weber, H. Mitsuya. Acc. Chem. Res. 2008, 41, 78-86.

157. "Enantioselective total synthesis of Peloruside A, a potent Microtubule Stabilizer" A. K. Ghosh, X. Xu, J.-H. Kim, C.-X. Xu. Org. Lett. 2008, 10, 1001-1004.

156. "Potent memapsin 2 (beta-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation" A. K. Ghosh, N. Kumaragurubaran, L. Hong, S. Kulkarni, X. Xu, H. B. Miller, D. S. Reddy, V. Weerasena, R. Turner, W. Chang, G. Koelsch, J. Tang. Bioorg. Med. Chem. Lett. 2008, 18 ,1031-1036.

155. "Development of Protease Inhibitors and the Fight with Drug-Resistant HIV-1 Variants” H. Mitsuya, K. Maeda, D. Das, A. K. Ghosh. Advances in Pharmacology, 2007, 56, 169-197.

154. "Darunavir, a Conceptually New HIV-1 Protease Inhibitor for the Treatment of Drug-resistant HIV” A. K. Ghosh, Z. L. Dawson, H. Mitsuya. Bioorg. Med. Chem. 2007, 15, 7576-7580.

153. "Potent Inhibition of HIV-1 Replication by Novel Non-peptidyl Small Molecule Inhibitors of Protease Dimerization” Y. Koh, S. Matsumi, D. Das, M. Amano, D. A. Davis, J. Li, S. Leschenko, A. Baldridge, T. Shioda, R. Yarchoan, A. K. Ghosh, H. Mitsuya. J. Biol. Chem. 2007, 282, 28709-28720.

152. “Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors” A. K. Ghosh, K. Xi, V. Grum-Tokars, X. Xu, K. Ratia, W. Fu, K. V. Houser, S. C. Baker, M. E. Johnson, A. D. Mesecar. Bioorg. Med. Chem. Lett. 2007, 17, 5876-5880.

151. "Enantioselective Synthesis of (-)-Platensimycin Oxatetracyclic Core using an Intramolecular Diels Alder Reaction" A. K. Ghosh and K. Xi. Org. Lett. 2007, 9, 4013-4016.

150. "Memapsin 2 (Beta-Secretase) Inhibitor Drug, between Fantasy and Reality" A. K. Ghosh, G. Bilcer, L. Hong, G. Koelsch, J. Tang. Curr. Alz. Res. 2007, 4, 418.

149. "Potent New Antiviral Compound Shows Similar inhibition and Structural Interactions with Drug Resistant Mutants and Wild Type HIV-1 Protease" Y.-F. Wang, Y. Tie, P. I. Boross, J. Tozser, A. K. Ghosh, R. W. Harrison, I. T. Weber. J. Med. Chem. 2007 , 50, 4509-4515.

148. "A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus in Vitro" M. Amano, Y. Koh, D. Das, J. Li, S. Leschenko, Y.-F. Wang, P. I. Boross, I. T. Weber, A. K. Ghosh, H. Mitsuya. Antimicrob. Agents Chemother. 2007, 51, 2143-2155.

147. "Enantioselective Total Synthesis of (+)-Jasplakinolide" A. K. Ghosh, and D. K. Moon, Org. Lett. 2007, 9, 2425-2427.

146. "Design, Synthesis and X-ray Structure of Potent Memapsin 2 (b -Secretase) Inhibitors with Functionalized Aromatic derivatives as the P2-P3-Ligands" A. K. Ghosh, N. Kumaragurubaran, L. Hong, S. Kulkarni, X. Xu, W. Chang, V. Weerasena, R. Turner, G. Koelsch, G. Bilcer, J. Tang. J. Med. Chem. 2007, 50, 2399-2407.

145. "Enantioselective Total Synthesis of Antitumor Macrolide Lasonolide A" A. K. Ghosh and G. Gong. Organic Letters 2007, 9, 1437-1440.

144. "Atomic Resolution crystal Structures of HIV-1 Protease and MutantsV82A and I84V with Saquinavir" Y. Tie, A. Y. Kovalevsky, P. Boross, Y.-F. Wang, A. K. Ghosh, J. Tozser, R. W. Harrison, I. T. Weber. Proteins 2007, 67, 232-242.

143. "Synergistic Effects of Peloruside A and Laulimalide with Taxoid site Drugs, but not with Each other, on Tubulin Assembly" E. Hamel, B. W. Day, J. H. Miller, M. K. Jung, P. T. Northcote, A. K. Ghosh, D. P. Curan, M. Cushman, K. C. Nicolaou, I. Paterson, E. J. Sorenson. Mol. Pharmacology 2006, 70, 1555-1564.

142. "Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy" A. K. Ghosh, K. Xi, M. E. Johnson, S. C. Baker, A. D. Mesecar. Ann. Rep. Med. Chem. 2006, 41, 183-196.

141. "Bis-Tetrahydrofuran: A Privileged Ligand for Darunavir and a New Generation of HIV-Protease Inhibitors That Combat Drug-Resistance" A. K. Ghosh, S. P. Ramu, N. Kumaragurubaran, Y. Koh, I. T. Weber, H. Mitsuya. ChemMedChem 2006, 1, 939-950.

140. "Design, Synthesis and X-ray Structure of Protein-Ligand Complexes: Important Insight into Selectivity of Memapsin 2 (b -Secretase) Inhibitors" A. K. Ghosh, N. Kumaragurubaran, L. Hong, H. Lei, K. A. Hussain, C. Liu, T. Devasamudram, V. Weerasena, R. Turner, G. Koelsch, G. Bilcer, and J. Tang, J. Am. Chem. Soc. 2006, 128, 5310-5311

139. "Asymmetric Multicomponent Reactions: Diastereoselective Synthesis of Substituted Pyrrolidines and Prolines" A. K. Ghosh, S. Kulkarni, C.-X. Xu, P. E. Fanwick. Organic Letters 2006, 8, 4509-4511.

138. "Ultra-high Resolution Protein-ligand X-ray Structure of TMC 114: Identification of Novel Drug-binding sites" A. Y. Kovalevsky, F. Liu, S. Leshchenko, A. K. Ghosh, J. M. Louis, R. W. Harrison, I. T. Weber. J. Biol. Chem. 2006, 363, 161-173.

137. "A Stereoselective Anti-aldol Route to (3R,3aS,6aR)-Tetrahydro-2H-furo[2,3-b]furan-3-ol: A Key Ligand for a New Generation of HIV Protease Inhibitors" A. K. Ghosh, J. Li, S. P. Ramu. Synthesis 2006, 3015-3019.

136. "Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance" A. K. Ghosh, S. P. Ramu, S. Leshchenko, A. K. Hussain, J. Li, A. Kovalevsky, D. E. Walters, J. E. Wedekind, V. Grum-Tokars, D. Das, Y. Koh, K. Maeda, H. Gatanaga, I. T. Weber, H. Mitsuya. J. Med. Chem. 2006, 49, 5252-5261.

135. “Total synthesis and structural Revision of Amphidinolide W ” A. K. Ghosh and G. Gong, J . Org. Chem. 2006, 71 , 1085-1093.

134. “Altered HIV-1 gag Protein Interactions with Cyclophilin A (CypA) on the Acquisition of H219Qand H219P Substitutions in the CypA Binding Loop” H. Gatanaga, D. Das, Y. Suzuki, D. D. Yeh, M. F. Kavlick, K. A. Hussain, A. K. Ghosh, H. Mitsuya, J. Biol. Chem. 2006281, 1241-1250.

133. “Effectiveness of Nonpeptide Clinical Inhibitor (TMC-114) on HIV-1 Protease with Highly Drug Resistant Mutations D30N, I50V and L90M” A. Kovalevsky, Y. Tie, F. Liu, P. I. Boross, Y-F. Wang, S. Leshchenko, A. K. Ghosh and I. T. Weber. J. Med. Chem. 2006, 49, 1379-1387.

132. “Design and Synthesis of Novel HIV-1 protease inhibitors incorporating oxindoles as the P'2-ligands” A. K. Ghosh, G. Schiltz, S. Leschenko, S. Kay, D. E. Walters,and H. Mitsuya, Bioorg. Med. Chem. Lett. 2006, 16, 1869-1873.

131. "Design and Synthesis of Peptidomimetic SARS-3CLpro Inhibitors” A. K. Ghosh, K. Xi, K. Ratia, B. D. Santarsiero, W. Fu, B. H. Harcourt, P. A. Rota, S. C. Baker, M. E. Johnson and A. D. Mesecar. J. Med. Chem. 2005, 48, 6767-6771.

130. “Conformations of Laulimalide in DMSO-d6” P. Thepchatri, D. O. Cicero, E. Monteagudo, A. K. Ghosh, B. Cornett, E. R. Weeks, J. P. Snyder. J. Am. Chem. Soc. 2005, 127, 12838-12846.

129. “Recent Development of Structure-based b-Secretase Inhibitors for Alzheimer’s disease” A. K. Ghosh, K. Nagaswamy, J. Tang. Curr. Med. Chem. 2005, 16, 1609-1622.

128. “Cycloamide-based Protease Inhibitors Involving P1- and P2-ligands: A Ring Closing Olefin Metathesis Based Strategy” A. K. Ghosh, L. M. Swanson, H. Cho, K. A. Hussain, S. Leschenko, S. Kay, D. E. Walters,and H. Mitsuya, J. Med. Chem. 2005, 48, 3576-3585.

127. “UIC-94017/TMC114: A Novel protease Inhibitors Containing bis-Tetrahydrofuranyl Urethane (bis-THF) Potent Against Multi-PI-Resistant HIV in vitro“ Y. Koh, A. K. Ghosh and H. Mitsuya, J. AIDS Res. 2005, 7, 17-21.

126. “Structure Based Design of Cycloamide-urethane-Derived Novel Inhibitors of Human Brain Memapsin 2 (b-Secretase)” A. K. Ghosh, T. Devasamudram, L. Hong, C. DeZutter, X. Xu, V. Weerasena, G. Koelsch, G. Bilcer, and J. Tang, Bioorg. Med. Chem. Lett. 2005, 15, 15-20.

125. “Analysis of amyloid precursor protein processing protease  -secretase: tools for memapsin 2 (b-secretase) inhibition studies” G. Koelsch, V. Weerasena, D. Shin, A. K. Ghosh, J. Tang, Amyloid Precursor Protein 2005, 41-50.

124. “Memapsin 2 (b-Secretase) New Subsites S5, S6 and S7: Structural Locations and Functional Roles“ R. T. Turner, L. Hong, G. Koelsch, A. K. Ghosh and J. Tang, Biochemistry, 2005, 44, 105-112.

123. "TiCl4 Promoted Multicomponent Reaction: a New Entry to the Functionalized  -Amino Acids” A. K. Ghosh, C-X. Xu, D. Wink Org. Lett. 2005, 7, 7-10.

122. “Stereoselective Photochemical 1,3-Dioxalene Addition to a,b Unsaturated–g-lactone: Synthesis of Bis-tetrahydrofuranyl Ligand for HIV Protease Inhibitor UIC-94-017 (TMC-114)” A. K. Ghosh, S. Leshchenko and M. Noetzel, J. Org. Chem. 2004, 69, 7822-7829.

121. “Total Synthesis and Structural Revision of (+)-Amphidinolide W” A. K. Ghosh and G. Gong, J. Am. Chem. Soc. 2004, 126, 3704-3705.

120. "Stereoselective Chloroacetate Aldol Reaction: Synthesis of Acetate Aldol equivalents and Darzens Glycidic Esters” A. K. Ghosh, J.-H. Kim, Org. Lett. 2004, 6, 2725-2728.

119. “Assignment of Absolute Stereochemistry and Total synthesis of Spongidepsin” A. K. Ghosh and X. Xu. Organic Letters 2004, 6, 2055-2058.

118. “Oxazols: Synthesis, Reactions and spectroscopy of Chiral Bis(oxazolines)”, Edited by D. Palmer for Heterocyclic Compounds series, A. K. Ghosh, S. Fidanze, G. Bilcer, Wiley Interscience, 2004, 60, 595-634.

117. “In vivo inhibition of Ab production by memapsin 2 (b-secretase) inhibitors” W-P Chang, G. Koelsch, ,S. Wong, D. Downs, H. Da, V. Weerasena, B. Gordon, T. Devasamudram, G. Bilcer, A. K. Ghosh and J. Tang. J. Neurochem. 2004, 89, 1409-1416.

116. “Laulimalide and PacliTaxel: A Comparison of Their Effects on Tubulin Assembly and Their Synergistic Action When Present Simultaneously” E. J. Gapud, R. Bai, A. K. Ghosh and E. Hamel, Mol. Pharmacology, 2004, 66, 113-121.

115. “High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active against Multi-Drug Resistant Clinical Strains” Y. Tie, P. I. Boross, Y-F Wang, L. Gaddis, A. K. Hussain, S. Leshchenko, A. K. Ghosh, J. M. Louis, R. W. Harrison, I. T. Weber, J. Mol. Biol. 2004, 338, 341-352.

114. “Asymmetric Syntheses of Potent Antitumor Macrolides Cryptophycin B and Arenastatin A” A. K. Ghosh and A. Bischoff, Eur. J. Org. Chem. 2004, 10, 2131-2141.

113. "First Total Synthesis of (+)-Amphidinolide T1" A. K. Ghosh, C. Liu, Strategies and Tactics in Organic Synthesis, Academic Press, Edited by M. Harmata, 2004, 5, 255.

112. “The Development of Titanium Enolate Based Aldol Reaction” Edited by Rainer Mahrwald for 'Modern Aldol Reactions' A. K. Ghosh, M. Shevlin, WILEY-VCH, 2004, 63-121.

111. “Memapsin 2 (b-secretase), a drug target for Alzheimer’s disease” G. Koelsch, R. Turner, L. Hong A. K. Ghosh, J. Tang, Biochem. Soc. Symp. 2003, 70, 213-220.

110. "Enantioselective Synthesis of (+)-Cryptophycin 52 (LY355703), A Potent Antimitotic Antitumor Agent" A. K. Ghosh, L. Swanson, J. Org. Chem. 2003, 68, 9823-9826.

109. “Memapsin 2, a drug target for Alzheimerís disease” in J. Saklatvala et al. (eds.) "Protease and the Regulation of Biological Process” Portland Press. G. Koelsch, R. T. Turner, 3rd, L. Hong, A.K. Ghosh, and J. Tang, 2003, 312-320.

108. “A Novel bis-Tetrahydrofuranylurethane-containing Non-peptide Protease Inhibitor (PI) UIC-94017 (TMC114) Potent Against Multi-PI-Resistant HIV In Vitro" Y. Koh, H. Nakata, K. Maeda, H. Ogata, G. Bilcer, T. Devasamudram, J. K. Kincaid, P. Boross, Y. Tie P. Volarath, L. Gaddis, R. W. Harrison, I. T. Weber, A. K. Ghosh,. H. Mitsuya, Antimicrobial Agents and Chemotherapy, 2003, 47, 3123-3129.

107. “Synthetic Studies of Microtubule Stabilizing Agent Peloruside A: An Asymmetric Synthesis of the C10-C24 Segment” A. K. Ghosh, J-H. Kim, Tetrahedron. Lett. 2003, 44, 7659-7661.

106. “Study of memapsin 2 (b-secretase) and strategy of inhibitor design” J. Tang, A. K. Ghosh, L. Hong, G. Koelsch, R. Turner, W. J. Chang, J. Mol. Neuroscience 2003, 20, 299-304.

105. “Enantioselective Total Synthesis of (+)-Amphidinolide T1” A. K. Ghosh, C. Liu, J. Am. Chem. Soc. 2003, 125, 2374-2375.

104. “An Enantioselective Synthesis of the C1-C9 Segment of Antitumor Macrolide Peloruside A” A. K. Ghosh, J.-H. Kim, Tetrahedron. Lett. 2003, 44, 3967-3970.

103. “Highly Diastereoselective Anti-Aldol Reactions Utilizing Titanum Enolate of Cis-2-Arylsulfonamido -1-acenaphthenyl propionate” A. K. Ghosh, J.-H. Kim, Org. Lett. 2003, 6, 1063-1066.

102. “A Enantioselective Synthesis of thecore unit of the Non-nucleoside Reverse Transcriptase Inhibitor Taurospongin A” A. K. Ghosh and H. Lei. Tetrahedron: Asymm. 2003, 14, 629-634.

101. "Asymmetric Total Synthesis of the Gastroprotective Microbial Agent AI-77-B" A. K. Ghosh, A. Bischoff and J. Cappiello, Eur. J. Org. Chem. 2003, 5, 821-832.

100. “Multicomponent Reactions: Synthesis of Spirocyclic Tetrahydropyran Derivatives by Prins Cyclization,” A. K. Ghosh, D. Shin and G. Schiltz, Heterocycles, 2002, 58, 659-666.

99. “The Microtubule Stabilizing Agent Laulimalide Does not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May not Require its Epoxide Moiety for Activity” D. E. Pryor, A. O’Brate, G. Bilcer, J. Fernando Diaz, Y. Wang, Y. Wang, M. Kabaki,M. K. Jung, J. M. Andreu, A. K. Ghosh, P. Giannakakou, E. Hamel, Biochemistry, 2002, 41, 9109-9115.

98. “Chelation-Controlled Reduction: Stereoselective Formation of syn-1,3-diols and Synthesis of Compactin and Mevinolin Lactone” A. K. Ghosh and H. Lei, J. Org. Chem. 2002, 67, 8783-8788.

97. “Memapsin 2 (b-Secretase) as a therapeutic target” L. Hong, R. T. Turner, G. Koelsch, A. K. Ghosh, J. Tang, Biochem. Soc. Trans. 2002, 30, 530-534.

96. “Chelation Controlled Ester-Derived Titanium Enolate Aldol Reaction: Diastereoselective Syn-Aldols with Mono- and Bidentate Aldehydes” A. K Ghosh and J-H. Kim, Tetrahedron Letters 2002, 43, 5621-5624.

95. “Crystal Structure of Memapsin 2 (b-Secretase) in Complex with an Inhibitor OM00-3” L. Hong, R. T. Turner, G. Koelsch, D. Shin, A. K. Ghosh, J. Tang, Biochemistry, 2002, 41, 10963-10967.

94. “Doliculide, a New Macrocyclic Desipeptide Enhancer of Actin Assembly” R. Bai, D. G. Covell, A. K. Ghosh, C. Liu, E. Hamel, J. Biol. Chem. 2002, 277, 32165-32171.

93. “Specificity of Memapsin 1 and its Implications on the Design of Memapsin 2 (b-Secretase) Inhibitor Selectivity” R. T. Turner, J. A. Loy, C. Nguyen, T. Devasamudram, A. K. Ghosh, G. Koelsch, J. Tang, Biochemistry, 2002, 41, 8742-8746.

92. “A Non-Antibacterial Oxazolidinone that inhibits Epithelial Cell Sheet Migration” K. T. Mchenry, S. V. Ankala, A. K. Ghosh, G. Fenteany, ChemBioChem, 2002, 3, 1105-1111

91. “Novel Cyclourethane-Derived HIV Protease Inhibitors: A Ring Closing Olefin Metathesis Based Strategy” A. K. Ghosh, L. M. Swanson, C. Liu, K. A. Hussain, H. Cho, D. E. Walters, L. Holland,and J. Buthod, Bioorg. Med. Chem. Lett. 2002, 12, 1993-1996.

90. “A Potent HIV-1 Protease Inhibitor, UIC-94003: (TMC-126), and Selection of a Novel (A28S) Mutation in the Protease Active Site” K. Yoshimura, R. Kato, M. K. Kavlick, A. Nguyen, V. Moroun, K. Maeda, K. A. Hussain, A. K. Ghosh, J. Erickson, H. Mitsuya, J. Virol. 2002, 76, 1349-1358.

89. “Stereoselective Synthesis of the C11-N26 Fragment of Griseoviridin” A. K. Ghosh, H. Lei, Synthesis, 2002, 371-374.

88. “b-Secretase as a Therapeutic Target for Inhibitor Drugs” A. K. Ghosh, L. Hong and J. Tang. Curr. Med. Chem. 2002, 9, 1135-1144.

87. “Antiviral Activity of UIC-PI, a Novel Inhibitor of the Human Immunodeficiency Virus Type 1 Protease” A. K. Ghosh, E. Pretzer, H. Cho, K. A. Hussain, N. Duzgunes, Antiviral Research , 2002, 54, 29-36.

86. “Syntheses of FDA Approved HIV Protease Inhibitors” A. K. Ghosh, G. Bilcer and G. Schiltz, Synthesis, 2001, 2203-2229.

85. “Total Synthesis of Microtubule-stabilizing Agent (-)-Laulimalide” A. K. Ghosh, Y. Wang and J. T. Kim, J. Org. Chem. 2001, 66, 8973-8982.

84. “Structure Based Design: Potent Inhibitors of Human Brain Memapsin 2 (b-Secretase)” A. K. Ghosh, G. Bilcer, C. Harwood, R. Kawahama, D. Shin, K. A. Hussain, L. Hong, J. A. Loy, C. Nguyen, G. Koelsch, J. Ermolieff and J. Tang, J. Med. Chem. 2001, 44, 2865-2868.

83. “Stereoselective Synthesis of Pseudopeptide Microbial Agent AI-77B”A. K. Ghosh, A. Bischoff and J. Cappiello, Organic Letters 2001, 3, 2677-2680.

82. “Subsite Specificity of Memapsin 2 b-Secretase): Implications for Inhibitor Design” R. Turner, G. Koelsch, L. Hong, P. Castenheira, A. K. Ghosh and J. Tang, Biochemistry 2001, 40, 10001-10006.

81. “Asymmetric Hetero Diels-Alder Route to Quaternary Carbon Centers: Synthesis of (-)-Malyngolide” A. K. Ghosh and M. Shirai, Tetrahedron Letters 2001, 42, 6231-6233.

80. "Total Synthesis of Antitumor Depsipeptide (-)-Doliculide" A. K. Ghosh and Chunfeng Liu, Organic Letters 2001, 3, 635-638.

79. “Structure-based Design of Nonpeptide HIV Protease Inhibitors” A. K. Ghosh, D. Shin, L. Swanson, K. Krishnan, H. Cho, K. A. Hussain, D. E. Walters, L. Holland, J. Buthod, Farmaco 2001, 56, 29-32.

78. “A Macrolactonization Strategy to Microtuble-Stabilizing Agent (-)-Laulimalide” A. K. Ghosh and Y. Wang, Tetrahedron Letters 2001, 42, 3399-3401.

77. “Tartaric Acid and Tartrates in the Synthesis of Bioactive Molecule” A. K. Ghosh, E. Koltun, G. Bilcer, Synthesis, 2001, 1281-1301.

76. “2,5-Anhydro Sugar Diacid and 2,5-Anhydro Sugar Diamine Based C2-Symmetric Peptidomimetics as Potential HIV-1 Protease Inhibitors" T. K. Chakraborty, S. Ghosh, M. H. V. Ramana Rao, A. C. Kunwar, H. Cho, A. K. Ghosh, Tetrahedron Letters 2001, 42, 10121-10125.

75. “Ester Derived Titanium Enolate Aldol Reaction : Chelation Controlled Diastereoselective Synthesis of Syn-Aldols” A. K. Ghosh and J-H. Kim, Tetrahedron Letters, 2001, 42 1227-1231.

74. “Structure of Memapsin 2 with Inhibitor, A Template to Design Drugs for Alzheimer’s Disease” L. Hong, G. Koelsch, X. Lin, S. Terzyan, A. K. Ghosh, X. C. Zhang and J. Tang, Science, 2000, 290 , 150-153.

73. “Stereoselective Construction of Quaternary Carbon Centers by Three Component Coupling Reactions” A. K. Ghosh; R. Kawahama and D. Wink, Tetrahedron Letters, 2000, 44, 8425-8429.

72. “Total Synthesis of (+)-Laulimalide, A potent Antitumor Macrolide" A. K. Ghosh and Y. Wang, J. Am. Chem. Soc. 2000, 122, 11027-11028.

71. “A Convergent Synthesis of (+)-Cryptophycin B, A potent Antitumor Macrolide from Nostoc sp. Cyanobacteria " A. K. Ghosh and A. Bischoff, Organic Letters, 2000, 2, 1573-1575.

70. “Enzymatic Acylation and Ring Closing Olefin-metathesis: A Convenient Strategy for the Lactone Moiety of Compactin and Mevinolin " A. K. Ghosh and H. Lei, J. Org. Chem. 2000, 65, 4779-4781.

69. “A Short Synthesis of (±)-Eburnamonine " A. K. Ghosh and R. Kawahama, J. Org. Chem. 2000, 65, 5433-5435.

68. “Asymmetric Synthesis of (-)-Tetrahydrolipstatin: An Anti-Aldol Based Strategy " A. K. Ghosh and S. Fidanze, Organic Letters, 2000, 2, 2405-2407.

67. “Synthetic Studies of Antitumor Macrolide Laulimalide: A Stereoselective Synthesis of the C17-C28 Segment" A. K. Ghosh and Y. Wang, Tetrahedron Letters, 2000, 41, 4705-4708.

66. “An Enantioselective Synthesis of the C2-C16 Segment of Antitumor Macrolide Laulimalide " A. K. Ghosh and Y. Wang, Tetrahedron Letters, 2000, 41, 2319-2322.

65. “Design of Potent Inhibitors for Human Brain Memempsin 2 (b-Secretase)” A. K. Ghosh, D. Shin, D. Downs, G. Koelsch, X. Lin, J. Ermolieff and J. Tang, J. Am. Chem. Soc. 2000, 122, 3522-3523.

64. “A Stereoselective Synthesis of (+)-Boronolide” A. K. Ghosh and G. Bilcer. Tetrahedron Letters 2000, 41, 1003-1006.

63. “Counterions of BINAP-Platinum and Palladium Complexes: Novel Catalysts for Highly Enantioselective Diels-Alder Reaction” A. K. Ghosh and H. Matsuda. Organic Letters 1999, 1, 2157-2159.

62. “Stereoselective synthesis of 5-O-Carbamoylpolyoxamic Acid by [2,3]-Wittig-Still Rearrangement” A. K. Ghosh and Y. Wang, Tetrahedron 1999, 55, 13369-13376.

61. “Synthetic Studies of Nucleoside Antibiotics: A Formal Synthesis of (+)-Sinefungin” A. K. Ghosh and Y. Wang, J. Chem. Soc. Perkin Trans. 1 1999, 3597-3601.

60. “A Stereoselective Synthesis of (-)-Tetrahydrolipstatin” A. K. Ghosh and C. Liu, Chem. Comm. 1999, 1743-1744.

59. “Asymmetric Dihydroxylation Route to Dipeptide Mimetic for HIV Protease Inhibitors: Enantioselective Synthesis of the Core Unit of Ritonavir” A. K. Ghosh, D. Shin and P. Mathivanan, Chem. Commun. 1999, 1025-1026.

58. “TiCl4 Promoted Three Component Coupling Reaction: an Efficient Method for the Substituted Tetrahydropyrilidene Acetates” A. K. Ghosh, R. Kawahama, Tetrahedron Letters 1999, 40, 4751-4754.

57. "Stereoselective Total Synthesis of Polyoxin J“ A. K. Ghosh and Y. Wang, J. Org. Chem. 1999, 64, 2789-2795.

56. "TiCl4 Promoted Three Component Coupling Reaction : A New Synthetic Method for the Functionalized Tetrahydrofuran and Tetrahydropyran“ A. K. Ghosh and R. Kawahama, Tetrahedron Letters, 1999, 40, 1083-1086.

55. “Stereoselective Synthesis of Dihydroisocoumarin Moiety of Microbial Agent AI-77-B: A Diels-Alder Based Strategy” A. K. Ghosh and J. Cappiello, Tetrahedron Letters, 1998, 39, 8803-8806.

54. “Stereoselective Synthesis of Protected Thymine Polyoxin C via [2,3]-Wittig-Still Rearrangement of Ribose Derived Allylic Stannyl Ethers “ A. K. Ghosh and Y. Wang, J. Org. Chem. 1998, 63, 6735-6738.

53. "Constrained Bis(oxazoline) Derived Cationic Aqua Complexes: Highly Effective Catalysts for Enantioselective Diels-Alder Reactions” A. K. Ghosh, H. Cho and J. Cappiello, Tetrahedron : Asymmetry, 1998, 9, 3687-3691.

52. “Transition-State Mimetics for HIV Protease Inhibitors: Stereocontrolled Synthesis of Hydroxyethylene and Hydroxyethylamine Isosteres by Ester Derived Titanium Enolate Syn- and Anti-aldol Reactions” A. K. Ghosh and S. Fidanze, J. Org. Chem. 1998, 63, 6146-6152.

51. “Ring-Closing Metathesis Strategy to a,b-unsaturated g- and d-Lactones: Synthesis of Hydroxyethylamine Isosteres for HIV Protease Inhibitors” A. K. Ghosh, J. Cappiello and D. Shin, Tetrahedron Letters, 1998, 8, 4651-4654.

50. “Cis-1-aminindan-2-ol in Asymmetric Syntheses” A. K. Ghosh, S. Fidanze and C. H. Senanayake, Invited Review, Synthesis, 1998, 937-961.

49. “Potent HIV Protease Inhibitors Incorporating High Affinity P2-Ligands and (R)-Hydroxyethylaminosufonamide Isostere” A. K. Ghosh, J. F. Kincaid, W. Cho, D. E. Walters, K. Krishnan, K. A. Hussain, Y. Koo, H. Cho, C. Rudall, L. Holland, J. Buthod, Bioorg. Med. Chem. Letters, 1998, 8, 687-690.

48. "Convenient Synthesis of Novel Macrocyclic Urethane: Alkoxycarbonylation of Amines and Ring-Closing Metathesis Strategy” A. K. Ghosh and K. A. Hussain, Tetrahedron Letters, 1998, 39, 1881-1884.

47. “Structure Based Design: Novel Spirocyclic Ethers as Nonpeptidal P2-Ligands for HIV Protease Inhibitors” A. K. Ghosh, K. Krishnan, D. E. Walters, W. Cho, Y. Koo, H. Cho, L. Holland, J. Buthod, Bioorg. Med. Chem. Letters, 1998, 8, 979-982.

46. “Chemoselective Reduction of Alkenes Using Lindlar Catalyst” A. K. Ghosh, K. Krishnan, Tetrahedron Letters, 1998, 39, 947-950.

45. “C2-Symmetric Chiral Bis(oxazoline)-metal Complexes in Catalytic Asymmetric Synthesis” A. K. Ghosh, P. Mathivanan, J. Cappiello, Invited Review, Tetrahedron: Asymmetry, 1998, 9, 1-45.

44. "A Convergent, Enantioselective Total Synthesis of Streptogramin Antibiotic (-)-Madumycin II" A. K. Ghosh and W-M. Liu, J. Org. Chem. 1997, 62, 7908-7909.

43. "Ester Derived Titanium Enolate Aldol Reaction: Highly Diastereoselective Synthesis of Syn- and Anti-aldols" A. K. Ghosh, S. Fidanze, M. Onishi, A. Hussain, Tetrahedron Letters , 1997, 38, 7171-7174.

42. "Asymmetric Aldol Route to Hydroxyethylamine Dipeptide Isostere: Convenient Synthesis of HIV Protease Inhibitor Saquinavir" A. K. Ghosh, A. Hussain, S. Fidanze, J. Org. Chem. 1997, 62, 6080-6082.

41. "Synthetic studies of Antitumor Macrolide Laulimalide: Enantioselective Synthesis of the C1-C14 Segment by a Catalytic Hetero Diels-Alder Strategy" A. K. Ghosh, P. Mathivanan, J. Cappiello. Tetrahedron Letters 1997, 38, 2427-2430.

40. "A Convenient Enzymatic Route to Optically Active 1-Aminoindan-2-ol: Versatile Ligands for HIV-1 Protease Inhibitors and Asymmetric Syntheses" A. K. Ghosh, J. F. Kincaid and M. Haske. Synthesis 1997, 541-544.

39. "Asymmetric Alkylations and Aldol Reactions : Optically Active 1, 2-aminocyclo-pentanol Derived New Chiral Auxiliaries" A. K. Ghosh, H. Cho. Tetrahedron: Asymmetry, 1997, 8, 821-824.

38. "Total Synthesis of (+)-Sinefungin" A. K. Ghosh, W-M. Liu. J. Org. Chem. 1996, 61, 6175-6182.

37. "Heteroatom Diels-Alder Reaction with Danishefsky Diene: Bis(oxazoline) Based Asymmetric Catalysis" A. K. Ghosh, P. Mathivanan, J. Cappiello. Tetrahedron: Asymmetry, 1996, 7, 2165-2168.

36. "Conformationally Constrained Bis(oxazoline) Derived Chiral Catalyst: A Highly Effective Enantioselective-Catalytic Diels-Alder Reaction" A. K. Ghosh, P. Mathivanan, J. Cappiello. Tetrahedron Letters 1996, 37, 3815-3818.

35. "Synthesis of Enantiomerically Pure Anti Aldols: A Highly Stereoselective Ester-Derived Titanium Enolate Aldol Reaction" A. K. Ghosh, M. Onishi. J. Am. Chem. Soc. 1996, 118, 2527-2528.

34. "A Convergent, Enantioselective Total Synthesis of Hapalosin with Multidrug-Resistance Reversing Activity" A. K. Ghosh, W. M. Liu, Y. Xu, Z. Chen. Angew. Chem. 1996, 35, 74-76.

33. "Nonpeptidal P2-Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis and Biological Evaluations " A. K. Ghosh, J. F. Kincaid, D. E. Walters, Y. Chen, N. C. Chaudhuri, W. J. Thompson, C. Culberson, P. M.D. Fitzgerald, S. P. McKee, P. M. Munson, M.G. Axel, J. R. Huff; J. Med. Chem., 1996 39, 3278-3290.

32. "Highly Diastereoselective Asymmetric Diels-Alder Reactions of Arylsulfonamido-2-Indanols derived Ligands" A. K. Ghosh, P. Mathivanan, Tetrahedron: Asymmetry, 1996, 7, 375-378.

31. "Chiral Auxiliary Mediated Conjugate reduction and Asymmetric Protonation: Synthesis of High Affinity Ligands for HIV Protease Inhibitors", A. K. Ghosh, W. Liu, J. Org. Chem. 1995, 60, 6198-6201.

30. "Highly Stereoselective Reduction of a-keto Esters : Utility of Cis-1-Arylsulfonamido-2-Indanols as Chiral Auxiliaries", A. K. Ghosh Y. Chen. Tetrahedron Letters 1995, 36, 6811-6814.

29. "Cyclic Sulfone-3-Carboxamide as Novel P2-Ligands for HIV-1 Protease Inhibitors" A. K. Ghosh, W. J. Thompson, P. M. Munson, W. Liu, J. R. Huff. Bioorganic and Med. Chem. Letters, 1995, 5, 83-88.

28. "Synthesis and Optical Resolution of High Affinity P2-Ligands for HIV-1 Protease Inhibitors" A. K. Ghosh and Y. Chen. Tetrahedron Letters, 1995, 36, 505-508.

27. "A Priori Prediction of Activity for HIV-1 Protease Inhibitors Employing Energy Minimization in the Active Site" M. K. Holloway, P. M.D. Fitzgerald, W. J. Thompson, A. K. Ghosh, P. L. Darke, J. Zugay, E. A. Emini, W. A. Schleif, J. M. Wai, J. R. Huff and P. S. Anderson. J. Med. Chem., 1995, 38, 305-317.

26. "The Development of Cyclic Sulfolanes as Novel and High Affinity P2-Ligands for HIV-1 Protease Substrate Binding Site" A. K. Ghosh, W. J. Thompson, C. Culberson, M. K. Holloway, S. P. McKee, T. T. Duong, P. M. Munson, P. L. Darke, J. Zugay, E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson. J. Med. Chem. 1994, 37, 1177-1188.

25. "Structure Based Design of High Affinity Ligands for HIV-1 Protease Inhibitor: Replacements of Two Amides and a 10p Electron Aromatic System" A. K. Ghosh, W. J. Thompson, P. M.D. Fitzgerald, C. Culberson, S. P. McKee, J. R. Huff and P. S. Anderson. J. Med. Chem. 1994, 37, 2506-2508.

24. "Potent HIV Protease Inhibitors: The Development of 3'-tetrahydrofuranglycine as P2-Ligands and substituted Pyrazine Derivatives as P3-Ligands " A. K. Ghosh, W. J. Thompson, S. P. McKee, T. T. Duong, M. K. Holloway, H. Y. Lee, P. M. Munson, J. Wai, P. L. Darke, J. Zugay, E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson. J. Med. Chem., 1993, 36, 2300-2310.

23. "Cyclic sulfones as novel and High Affinity P2-Ligands for HIV Protease Inhibitors" A. K. Ghosh, W. J. Thompson, S. P. McKee, T. T. Duong, T. A. Lyle, J. C. Chen, P. L. Darke, J. Zugay, E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson. J. Med. Chem. 1993, 36, 924-927.

22. "3- tetrahydrofuran and pyranyl Urethanes as High Affinity P2-Ligands for HIV-1 Protease Inhibitors" A. K. Ghosh, W. J. Thompson, S. P. McKee, T. T. Duong, T. A. Lyle, J. C. Chen, P. L. Darke, J. Zugay, E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson. J. Med. Chem. 1993, 36, 292-294.

21. "3'-tetrahydrofuranglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease" W. J. Thompson, A. K. Ghosh, M. K. Holloway, H. Y. Lee, P. M. Munson, J. E. Schwering, J. Wai, P. L. Darke, J. Zugay, E. A. Emini, W. A. Schleif, J. R. Huff and P. S. Anderson. J. Am. Chem. Soc. 1993, 115, 801-803.

20. "Potent HIV-1 Protease Inhibitors : Stereoselective Synthesis of a New Dipeptide Mimic" A. K. Ghosh, S. P. McKee, W. J. Thompson, P. L. Darke, and J. Zugay. J. Org. Chem. 1993, 58, 1025-1029.

19. "HIV-1 Protease Inhibitors: Synthesis and biological Evalution of Glycopeptides" A. K. Ghosh, S. P. McKee, W. M. Sanders, P. L. Darke, J. Zugay, E. M. Emini, J. R. Huff and P. S. Anderson. Drug Design and Discovery 1993, 10, 77-88.

18. "Highly Enantioselective Aldol Reaction : Development of a New Chiral Auxiliary from cis-1-amino-2-hydroxyindane" A. K. Ghosh, T. T. Duong, S. P. McKee. J. Chem. Soc., Chem. Communication. 1992, 22, 1673-1674.

17. "An Efficient Synthesis of Functionalized Urethanes from Azides" A. K. Ghosh, S. P. McKee, T. T. Duong and W. J. Thompson. J. Chem. Soc., Chem. Communication. 1992, 18, 1308-1310.

16. "A Facile and Enantiospecific Synthesis of 2(S)- and 2(R)-[1'(S)-Azido-2-Phenylethyl]Oxirane" A. K. Ghosh, S. P. McKee, H. Y. Lee and W. J. Thompson. J. Chem. Soc., Chem. Communication. 1992, 3, 273-74.

15. "N,N'-Disuccinimidyl Carbonate: A Useful Reagent for Alkoxycarbonylation Of Amines" A. K. Ghosh, T. T. Duong, S. P. McKee and W. J. Thompson. Tetrahedron Letters 1992, 33, 2781-2784.

14. "Intramolecular and Intermolecular Hydroxyl Reactivity Differences in Ginkgolides A, B and C and Their Chemical Applications" E. J. Corey, K. Srinivas Rao and A. K. Ghosh. Tetrahedron Letters 1992, 33, 6955-6958.

13. "An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors" A. K. Ghosh, S. P. McKee, and W. J. Thompson. J. Org. Chem. 1991, 56, 6500-6503.

12. "Stereocontrolled Synthesis of HIV-1 Protease Inhibitors with C2-Axis of Symmetry" A. K. Ghosh, S. P. McKee, and W. J. Thompson. Tetrahedron Letters 1991, 32, 5729-5732.

11. "Di(2-Pyridyl) Carbonate Promoted Alkoxycarbonylation Of Amines: A Convenient Synthesis of Functionalized Carbamates" A. K. Ghosh, T. T. Duong and S. P. McKee. Tetrahedron Letters 1991, 32, 4251-4254.

10. "Stereoselective Reduction of a-Hydroxy Oxime Ethers: A Convenient Route to Cis-1,2-Amino Alcohols" A. K. Ghosh, S. P. McKee, and W. M. Sanders. Tetrahedron Letters 1991, 32, 711-714.

9. "Total Synthesis Of (±) Ginkgolide B" M. C. Desai, A. K. Ghosh, M-C. Kang, and I. N. Houpis, Strategies and Tactics in Organic Synthesis, Academic Press, Edited by T. Lindberg, 1991, 3, 89-119.

8. "Total Synthesis Of (±) Ginkgolide A" E. J. Corey and A. K. Ghosh. Tetrahedron Letters 1988, 29, 3205-3206.

7. "Total Synthesis Of (±) Ginkgolide B" E. J. Corey, M-C. Kang, M. C. Desai, A. K. Ghosh, and I. N. Houpis. J. Am. Chem. Soc. 1988, 110, 649-651.

6. "Two-step Synthesis of Furans by Mn(III)-Promoted Annulation of Enol Ethers" E. J. Corey and A. K. Ghosh. Chemistry Letters 1987, 223-226.

5. "Mn(III)-Promoted Annulation of Enol Ethers to Fused or Spiro 2-Cyclopentanones" E. J. Corey and A. K. Ghosh. Tetrahedron Letters 1987, 28, 175-178.

4. "Methods for Pyranoannulation - An Approach to a New Class of Polyethers" A. P. Kozikowski and A. K. Ghosh. J. Org. Chem. 1985, 50, 3017-3019.

3. "Diastereofacial Selection in Nitrile Oxide Cycloaddition Reactions. The Anti-Directing Effect of an Allylic Oxygen and Some New Results on the Ring Metalation of Isoxazolines. A Synthesis of (±) Blastmycinone" A. P. Kozikowski and A. K. Ghosh. J. Org. Chem. 1984, 49, 2762-2772.

2. "The Isoxazoline Route to a-Methylene Lactones" A. P. Kozikowski and A. K. Ghosh. Tetrahedron Letters 1983, 24, 2623-2626.

1. “Diastereoselection in Intramolecular Nitrile Oxide Cycloaddition (NOC) Reactions: Confirmation of the "Antiperiplanar Effect" Through a Simple Synthesis of 2-deoxy-D-ribose" A. P. Kozikowski and A. K. Ghosh. J. Am. Chem. Soc. 1982, 104, 5788-5789.