HubMap: Molecular Atlas of Human Tissues

Pancreatic islets, lipids, proteins and insulin.

Collaboration with PNNL (Piehowski, Burnum-Johnson), Marquette (Ye), Vanderbilt (Spraggins)

We are part of the HubMap Consortium focused on establishing a molecular atlas of human tissues. In this project, we have developed high-throughput nano-DESI MSI approaches using rapid scanning and deep learning-driven dynamic sparse sampling. We have also correlated nano-DESI MSI with nanoPOTS proteomics imaging along with autofluorescence and immunofluorescence imaging to obtain detailed maps of lipids, metabolites, and proteins in human pancreas, heart, and kidney.

Publications

HuBMAP Consortium. The human body at cellular resolution: the NIH Human Biomolecular Atlas Program. Nature 574, 187–192 (2019). https://doi.org/10.1038/s41586-019-1629-x