Proteoform-Selective Imaging of Tissues Using Mass Spectrometry

Collaboration with Northwestern (Kelleher)

Mass spectrometry imaging of tissues using nanospray desorption electrospray ionization provides first insights into the effect of post-translational modifications on the differential expression of individual proteoforms in biological tissues, which is important for understanding their function and interactions.

Publications

Yang, M.; Hang, H.; Su, P; Thomas, P. M.; Camarillo, J. M.; Greer, J. B.; Early, B. P.; Fellers, R. T.; Kelleher, N. L.; Laskin, J. Angew. Chem. Int. Ed. 2022, e202200721c