Multimodal Imaging

We are developing new approaches for multimodal imaging of biological systems, which will enable quantitative measurement of chemical gradients of molecules involved in cellular communication and in situ imaging of metabolic processes. Recently, we combined nano-DESI MSI with shear force microscopy which enabled simultaneous imaging of sample topography and chemical composition. This approach is particularly advantageous for imaging living microbial community and high-resolution tissue imaging.

Chemical ion image, surface topography, nano-DESI MSI, Shear-force microscopy and tissue

Publications

S. N. Nguyen, A. Liyu, R. K. Chu, C. R. Anderton, J. Laskin "Constant-Distance Mode Nanospray Desorption Electrospray Ionization Mass Spectrometry Imaging of Biological Samples with Complex Topography", Anal. Chem., 89, 1131-1137 (2017). DOI: 10.1021/acs.analchem.6b03293

S. N. Nguyen, R. L. Sontag, J. P. Carson, R. A. Corley, C. Ansong, J. Laskin "Towards High-Resolution Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry Coupled to Shear Force Microscopy", J. Am. Soc. Mass Spectrom., DOI: 10.1007/s13361-017-1750-8