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Biochemistry and Chemical Biology

Biochemistry offers cutting-edge research programs in the studies of biological systems. Our multidisciplinary programs encompass both fundamental and translational research, including elucidation of the molecular mechanisms in physiological and pathological states in cells and animal models. Our interdisciplinary projects include structural biology, signal transduction, design and synthesis of receptor-targeted imaging and therapeutic agents, tools for rapid detection and identification of pathogens, development of chemical and optical probes for drug discovery and small molecule therapeutics for various human diseases.

 

Fundamental advances in chemistry, biochemistry, and molecular biology have provided unprecedented opportunities to probe living systems at a molecular level. These advances have led to the development of a rapidly growing multidisciplinary field - Chemical Biology. Within Chemical Biology groundbreaking chemical methodology may be applied to the elucidation of essential biological processes. Additionally, newly identified biological targets may drive the development of unique chemical entities for a variety of drug discovery applications.

 

Apply to graduate school at Purdue University for Biochemistry and Chemical Biology today!


Our Faculty

Jean Chmielewski

Jean Chmielewski

  • Drug discovery
  • BioNanotechnology
  • Cellular delivery of therapeutic agents
Wesley Cochrane

Wesley Cochrane

  • RNA biochemistry and functional selections
  • High-throughput experimentation
  • Bio- and cheminformatics
Chittaranjan Das

Chittaranjan Das

  • Structural biology
  • Deubiquitinating enzymes
Bryon Drown

Bryon Drown

  • Drug interactions
  • Probe synthesis
  • Targeted native mass spectrometry
Shalini Low-Nam

Shalini Low-Nam

  • High spatiotemporal resolution imaging
  • Cancer and immune cell signaling
  • Lipid membrane dynamics
Angeline Lyon

Angeline Lyon

  • Structural and functional biochemistry
  • Signal transduction
  • Membrane biology
Andrew Mesecar

Andrew Mesecar

  • Structural biology
  • Enzyme kinetics
  • Molecular modeling
Lauren Ann Metskas

Lauren Ann Metskas

  • Cryo electron tomography
  • Correlative microscopy
  • Protein ultrastructure
Elizabeth (Betsy) Parkinson

Elizabeth (Betsy) Parkinson

  • Natural product synthesis and biosynthesis
  • Biocatalysis
  • Medicinal chemistry
Jonathan Schlebach

Jonathan Schlebach

  • Protein misfolding in the cell
  • Membrane protein biosynthesis and assembly
  • Molecular mechanisms of precision pharmacology
Shiliang Tian

Shiliang Tian

  • Metal ions homeostasis
  • Mechanism of magnetoreception
Danzhou Yang

Danzhou Yang

  • Structure biology
  • Drug discovery
  • Nucleic acid molecular targets for cancer
Emmanouil Zacharioudakis

Emmanouil Zacharioudakis

  • Drug discovery
  • Cancer biology
  • Mitochondrial biology
  • Medicinal chemistry
Zhong-Yin Zhang

Zhong-Yin Zhang

  • Medicinal chemistry
  • Chemical biology
  • Drug discovery