High Throughput Experimentation (HTE) Catalysis Center
The High Throughput Experimentation (HTE) Center at Purdue University accelerates the execution and analysis of chemical reactions for the purpose of discovering new transformations, optimizing catalysts systems and reaction conditions, evaluating the scopes of transformations, and synthesizing compound libraries. The experimental platform uses 24- and 96-well plates to execute large numbers of reactions in parallel. The facility houses a suite of analytical instruments, including LCMS, GCMS, and SFC, for the detection of new products and accurate determination of reaction conversions, yields and enantioselectivities. The center brings together researchers across Purdue's campus interested in using modern tools to accelerate the process of chemical synthesis.
Staff list
Leadership: Dr. Ming-Yu Ngai, Dr. Christopher Uyeda and Dr. Ryan Altman
Teaching Assistants: Arman Khosravi, Parijat Sharma
Location
Brown 1155
Instrument List
LCMS-2050 Single Quadrupole LC/MS System
The LCMS-2050 Single Quadrupole LC/MS system offers fast, high-throughput analysis and compound identification. The system is capable of sampling from a wide variety of sample vials, including 96-well and 384-well microtiter plate formats. The system includes the LCMS-2050 single quadrupole MS detector for high speed, high sensitivity detection and molecular weight determination as well as Photodiode Array detection for full spectral analysis of components. The system incorporates 6 column selection capabilities for method screening and method development. Data acquisition and analysis is performed by the LabSolutions-LCMS chromatography workstation.
Nexis GC-2030 Gas Chromatograph with AOC-6000 Autosampler
The GC-2030 Gas Chromatograph with Flame Ionization detector offers fast high-throughput analysis. The AOC-6000 robotic autosampler is capable of sampling from a wide variety of sample vials, as well as 96-well and 384-well microtiter plate formats. The system offers flexible injection options such as standard liquid injection and headspace injection. The GC-2030 is optimized for high speed and high-throughput capillary chromatography. Data acquisition and analysis is performed by the LabSolutions chromatography workstation.
Nexera UC LC-40 Supercritical Fluid Chromatography System
The Nexera LC-40 SFC System offers fast high-throughput analysis, capable of sampling from a wide variety of sample vials, including 96-well and 384-well microtiter plate formats. The system utilizes CO2 in its supercritical phase with a polar co-solvent to yield separations that prove difficult with normal phase or reverse phase chromatography. The system incorporates Photodiode Array detection for full spectral analysis of compounds. The system is capable of 6 column selection for method screening and method development. Data acquisition and analysis is performed by the LabSolutions chromatography workstation.
GCMS-QP2020 NX Gas Chromatograph Mass Spectrometer
The QP-2020 NX Single Quadrupole GC-MS system offers high-throughput analysis of sample components for compound identification. Configured with the AOC-6000 robotic autosampler, the system is capable of sampling from a wide variety of sample vials, as well as 96-well and 384-well microtiter plate formats. The system offers flexible injection options such as standard liquid injection and headspace injection. The QP-2020 NX is optimized for high speed and high-throughput capillary chromatography. Data acquisition and analysis is performed by the GCMSsolution chromatography workstation and incorporates the Wiley-NIST mass spectral library for compound identification.