All of these gases are dangerous due to toxicity. Some are dangerous via other qualities as well (flammable, reactive....).
REQUIRING WRITTEN APPROVAL ARE -- the white boldface on red background gases. Use of any quantity of any of these pure gases require Department approval in writing before the work begins, in the Dept of Chemistry and possibly other Depts. Mixtures containing these gases may also be included under the definition of highly toxic and require approval in writing.
CGA STANDARD FOR CLASSIFICATION OF TOXIC GAS MIXTURES
- acetyl fluoride ct
- antimony hydride
- arsenic pentafluoride
- boron trichloride
- boron trifluoride
- bromine chloride
- carbon monoxide
- carbonyl chlorofluoride
- carbonyl fluoride
- carbonyl sulfide
- chlorine dioxide
- chlorine monoxide
- chlorine pentafluoride
- chlorine trifluoride
- coal gas
- cyanogen chloride
- deuterium bromide
- deuterium chloride
- deuterium iodide
- deuterium sulfide
- dinitrogen tetroxide
- ethyl nitrite
- ethylene oxide
- hexaethyl tetraphosphate
- hydrogen bromide
- hydrogen chloride
- hydrogen cyanide
- hydrogen fluoride
- hydrogen iodide
- hydrogen selenide
- hydrogen sulfide
- methyl bromide
- methyl chloride
- methyl mercaptan
- mustard gas
- nickel carbonyl
- nitric oxide
- nitrogen dioxide
- nitrous oxide
- nitrogen trifluoride
- nitrogen trifluoride oxide
- nitrogen trioxide
- nitrosyl chloride
- oil gas
- oxalyl bromide
- oxygen difluoride
- perchloryl fluoride
- phosphorus pentafluoride
- selenium hexafluoride
- silicon tetrafluoride
- sulfur dioxide
- sulfur pentafluoride
- sulfur tetrafluoride
- sulfuryl fluoride
- tellurium hexafluoride
- trifluoroacetyl fluoride
- tungsten hexafluoride
- vinyl chloride
Poison Gases - see compiled list
Indiana Fire Code (8004.2.3.7)
Special requirements for highly toxic and toxic compressed gases:
Compressed gas cylinders shall be within gas cabinets, exhausted enclosures, or gas rooms. Gas cabinets and gas enclosures shall be in accordance with 8003.3.1.3.2 and 8003.3.1.3.3, respectively. Gas cabinets and gas enclosures shall be internally sprinklered.
8003.3.1.3.2 Gas cabinets must:
- operate at negative pressure w/re to surrounding area
- be provided with self-closing limited access pots or noncombustible windows to give access to equipment controls, average velocity at windows/port must be at least 200 fpm, min at any point 150 fpm
- be connected to an exhaust system
- be provided with self-closing doors
- be constructed of not less than 0.097" (12 gauge) steel.
8003.3.1.3.3 Exhausted enclosures must
Basically same as 1 and 2 above.
- 50 mg/kg < LD50 ≤ 500 mg/kg ( body weight) oral albino rat 200 - 300 g
- 200 mg/kg < LD50 ≤ 1000 mg/kg (body weight) continuous 24 h contact
(or less if death occurs before 24 h) albino rabbits 2 - 3 kg
- 200 ppm < LC50 ≤ 2000 ppm (by volume of gas or vapor), or 2 mg/L < LC50 ≤ 20 mg/L (dust, fume, mist) continuous inhalation for 1 h (or less if death occurs in less than 1 h) to albino rats 200 - 300 g.
- LD50 of ≤ 50 mg/kg body weight oral albino rat 200 - 300 g
- LD50 of ≤ 200 mg/kg body weight continuous 24 h contact (or less if death occurs before 24 h) albino rabbits 2 - 3 kg
- LC50 ≤ 200 ppm by volume of gas or vapor, or > 2 mg/L dust/fume/mist continuous inhalation for 1 h (or less if death occurs in less than 1 h) to albino rats 200 - 300 g.
Calculating for Gas Mixtures
Binary mixture = haz component + nonhaz rest, LC50m = 1/[Ci/LC50i]
LC50m = the LC50 of the mixture
Ci = concentration of component i in decimal percent
LC50i = LC50 of component i
MUST NORMALIZE for 1 h exposures via the table given A-VI-A-1 NORMALIZATION FACTOR
|TIME (hours)||Multiply by|
Chemistry Dept policy: any person(s) ordering or receiving liquefied or compressed gases on this list will comply with all State and Federal rules pertaining to their use and storage, and will prepare well written SOPs (written standard operating procedures) pertaining to each substance, addressing storage, handling, training, waste disposal, decontamination, and emergency procedures. No one will receive or handle such materials until after all qppropriate hazard assessments and training have been completed, and all staff working with and near the item(s) have been apprised of the hazards, the means of detecting releases, and the symptoms of exposure. (SOPs must address normal precautions pertaining to health and safety, as well as emergency procedures)
Note: low concentration mixtures of poson gas in inert gas are often not subject to the requirement for a fire-protected ventilated cabinet.
For table standing alone go to the Poison Gases Table. White type on red background indicates materials fitting the IFC definition of toxic or highly toxic. LC50 values are rat 1 h inhalation or equivalent as per chart above. Designations I, II, III, and NR are from the Santa Clara Co. TGO data and are included as a point of interest only.
Table still in progress: 12/10/09
|ammonia||4000||4000||80||Baker MSDS A5472 07/29/03 rat inh 4h 2000 ppm|
|antimony hydride||20||5||1% (1000 ppm)||20||10||0.67||0.40||see stibine below|
|arsenic pentafluoride||~1.5||5 mg As/m3||0.075% (750 ppm)||20||10||0.67||0.40||1.5 calculated from IDLH (just converted to ppm)|
|arsine||<0.9||3||0.045% (45 ppm)||20||10||0.67||0.40||
link 0.9 ppm is calc value from 15 min rat inh LC50 0.3 mg/m3
Air Liquide MSDS gives 20 ppm (1 h) LC50 with no other info.
BOC gas MSDS says 390 mg/m3/10M rat LC50
link DOES NOT SAY 1 h
RTECS data clear 2541 ppm is 1 h rat inh LC50
TOXNET LC50 Rat inhalation 1.21 mg/L/4 hr
RTECS data says 1180 mg/m3/4h Those are very close. The 875 is calculated based on the lewer of the two.
|bromine chloride||290||9.67||5.80||have searched RTECS, Toxnet (there is a Fact sheet from 1988, purchasable but probably not helpful). The use of this seems to be focused entirely on wastewater treatment and poliovirus pesticide activity.|
|carbon monoxide||3614||1200||3760||75.2||link 1807 ppm/4 hour(s) inhalation-rat LC50 RTECS gives same data|
|carbonyl chlorofluoride||45 ppm||class II||
|32.00||TGO assigned, failing tox data availability|
|carbonyl fluoride||360||18%||360||12.00||7.20||link 360 ppm/1 hour(s) inhalation-rat LC50|
|carbonyl sulfide||2140||2220||740||44.4||link 1070 ppm/4 hour(s) inhalation-rat LC50m RTECS agrees|
|chlorine||293||10||14.6%||9.77||5.86||link 293 ppm/1 hour(s) inhalation-rat LC50|
|chlorine dioxide||5||200 ppm||250||8.33||5.00||link (toxnet) gives much animal data but mostly aquatic.|
|chlorine monoxide||50 ppm||class I||50.00||3.33||2.00||TGO assigned, failing tox data availability|
|chlorine pentafluoride||122||6.1%||not in TGO||link (toxnet, might have to re-search, the links seem to "expire")|
|chlorine trifluoride||299||20||14.95%||299||9.97||5.98||link 299 ppm/1 hour(s) inhalation-rat LC50|
|coal gas||not in TGO||RTECS, not much tox data, appears to be quite bad.|
|cyanogen||350||17.5%||350||11.67||7.00||link 350 ppm/1 hour(s) inhalation-rat LC50|
RTECS 3150 μg/kg rabbit LD50
link 6 mg/kg oral-cat LD50
|diborane||80||15||link 40 ppm/4 hour(s) inhalation-rat LC50|
|deuterium iodide||class II||53.33||32.00|
|diazomethane||2||20||10.00||0.67||0.40||from TGO, IDLH|
|dichloroacetylene||438||153.1||76.56||5.10||3.06||link gives 4h rat LC50 for mixtures|
|dichlorosilane||215||314||10.47||6.28||RTECS (time not stated)|
|dinitrogen tetroxide||115||57.50||3.83||2.30||see nitrogen dioxide. They are in equilibrium.|
RTECS 800 ppm 4H rat inh LC50
toxnet says 1462 4H rat inh LC50
|fluorine||185||25||185||92.50||6.17||3.70||link 185 ppm/1 hour(s) inhalation-rat LC50|
|formaldehyde||784||20||165.7||82.84||5.52||3.31||toxnet says 0.48 mg/l (4 hr) rat which is 784 ppm 1h rat|
|germane||441||622||20.73||12.44||link 1380 mg/m3 inh-rat LC50; 1250 mg/kg oral-mouse LD50|
RTECS gives oral rat LD50 = 7 mg/kg
|hexafluoroacetone||468||470||15.67||9.4||RTECS has 275 ppm as 3h rat inh LC50|
|hydrogen bromide||2858||30||2860||95.33||57.20||link 2858 ppm/1 hour(s) inhalation-rat LC50|
link 3124 ppm/1 hour inh-rat LC50;
900 mg/kg oral-rabbit LD50
|hydrogen cyanide||112||50||40||20.00||1.33||0.80||link 160 ppm/30 min inh-rat LC50; 3700 ug/kg oral-mouse LD50|
|hydrogen fluoride||1347||30||1300||43.33||26.00||link 1100 mg/m3/60 minute(s) inhalation-rat LC50|
|hydrogen iodide||2860||95.33||57.20||not much tox reports, It seems to be of little interest for its toxicity.|
|hydrogen selenide||2.2||1||60||30.00||2.00||1.20||link 300 ppb/8 hour(s) inhalation-guinea pig LC50, RTECS confirms|
|hydrogen sulfide||444||100||712||23.73||14.24||link 444 ppm inhalation-rat LC50 (doesn't say 1 h) another link|
|methyl bromide||846||250||1007||33.57||20.14||link oral rat LD50 214 mg/kg
RTECS gives 302 ppm/8h rat LC50 and rat oral LD50 = 214 mg/kg
|methyl chloride||5143||2300||link IHL-RAT LC50 5300 mg/m3/4h
RTECS confirms and gives oral rat LD50 = 1800 mg/kg
|methylchlorosilane||600||20.00||12.00||not a lot of Tox data, RTECS gives some, no LC50 or LD50. It is apparetnly not an acute toxin of the same league.|
|methyl mercaptan||675||150||1350||45.00||27.00||link Ihl-rat 675 ppm (one h?) another link|
|mustard gas||4||2.00||0.13||0.08||not actually a gas at standard conditions|
|nickel carbonyl||24.5||2||link 35 ppm/30 min inhalation-rat LC50. not in TGO|
link IHL-RAT LC50 1068 mg/m3/4h, also reported in RTECS
link 160 mg/m3 inhalation-rat LC50, value also reported in RTECS
|nitrogen dioxide||176||20||115||57.50||3.83||2.30||link rat 4h inh 88 ppm|
|THIS is not a poison gas. It is "laughing gas," still used as a dental anesthetic, and it has been added to this table simply to make a point about how similar the names can look.|
|nitrogen trifluoride||6700||1000||link 6700 ppm/1 hour(s) inhalation-rat LC50, also in RTECS|
|nitrogen trifluoride oxide||48||RTECS gives 24 ppm 4 h rat inh LC50|
|nitrogen trioxide||3350||67.00||nothing in RTECS, little elsewhere, not finding tox data. "Delayed effects."|
|nitrosyl chloride||35||class II||53.33||32.00||link Air Liquide MSDS gives 35 ppm (1 h) LC50 with no other info.|
|oil gas||We will assume it's very bad and research it more thoroughly it it ever comes up.|
|oxalyl bromide||class II||53.33||32.00|
|oxygen difluoride||2.6||0.5||3||1.50||0.10||0.06||NIOSH RTECS|
|0.18||BOC 1997 msds says 4800 ppb 4 H rat inh which is pretty low|
|perchloryl fluoride||770||100||770||25.67||15.40||NIOSH RTECS gives 385 ppm/4 hour rat inh LC50|
|perfluoroisobutylene||1.47||1.2||0.61||0.04||0.02||BOC msds of mixture gives LC50 for this component as 1.05 ppm rat ihn 2 h|
|phosphine||22||200||20||10.00||0.67||0.40||link 11 ppm/4 hour(s) inhalation-rat LC50|
|phosphorus pentafluoride||190||260||8.67||5.20||Air Liquide MSDS gives 190 ppm (1 h) LC50 with no other info.|
|selenium hexafluoride||50||2||50||25.00||1.67||1.00||Air Liquide MSDS gives 50 ppm (1 h) LC50 with no other info.
RTECS gives only LCLOs, but it looks unpleasant.
|silicon tetrafluoride||450||2272||75.73||45.44||Air Liquide MSDS gives 450 ppm (1 h) LC50 with no other info.
RTECS gives 2250 ppm, no time.
|stibine||20||5||20||10||0.67||0.40||Air Liquide MSDS gives 20 ppm (1 h) LC50 with no other info.
RTECS -- all refs are LCLO, but they are pretty low.
|sulfur dioxide||2520||100||2520||84.00||50.40||Air Liquide MSDS gives 2520 ppm (1 h) LC50 with no other info.|
|sulfur pentafluoride||1||10||5.00||0.33||0.20||No rat inh data found. 10 is the IDLH according to TGO|
|sulfur tetrafluoride||40||40||20.00||1.33||0.80||Air Liquide MSDS gives 40 ppm (1 h) LC50 with no other info.|
|sulfuryl fluoride||3020||200||3020||60.40||Air Liquide MSDS gives 3020 ppm (1 h) LC50 with no other info.|
|1||25||12.5||0.83||0.50||Source of 25 ppm not known came from. RTECS only gives LCLO values, very low. OSHA tech bulletin also gives no LC50. NIOSH RTECS too|
|trifluoroacetyl fluoride||1000||33.33||20.00||tox info is elusive so far|
|trifluorochloroethylene||2000||NIOSH RTECS reports rat 4 h inh LC50 is 1000 ppm|
|tungsten hexafluoride||150||217||7.23||4.34||217 link Air Liquide MSDS gives 160 ppm (1 h) LC50 with no other info.|
|vinyl chloride||NR||Oxford msds says rat LD50 is 500 mg/kg, which is the upper limit of toxic. RTECS gives rat 15 min LC50 of 18 pph.|
*Reference is to material which is a compressed or liquefied gas or gas mixture obtained in cryo-freezers, cylinders, lecture bottles, or other gas containers. Does not apply liquid mixtures, e.g. BF3 etherate, nor aqueous NH3, HCl, HBr....
** IDLH is given as ppm unless otherwise indicated.
*** Cut-off concentration: If concentration of toxic gas in any two-component mixture compressed gas cylinder is LESS THAN this amount, the requirement for sprinklered, continuously ventilated cabinet does not apply.
*reference is to compressed and liquefied gases obtained in cryo-freezers, cylinders, lecture bottles, or other gas containers, not to purchased liquid mixtures, e.g. BF3 etherate, nor aqueous NH3, HCl, HBr....
** IDLH is given as ppm unless otherwise indicated.
See copy of DOT hazmat table for more info on hazard classes of materials. (The DOT hazmat table is the source of the designation of certain materials as Poison Gases.)
conc in ppm = (24.45)(conc in mg/m3)/(gram molecular weight of substance)
AsH3 calculation: (24.5) (0.3)/82.9 = 0.9 ppm (15 min)
BF3 calculation (24.5)(1210)/67.8 = 437.2 ppm (4h) normalize to 1 h ---> 875 ppm
HF calculation: (24.5)(1100)/20 = 1347 ppm
GeH4 calculation (24.5)(1380)/76.6 = 441 except it doesn't say 1 h in the original data....but even if it were 4 h it would still be toxic.....
COCl2 calculation (24.5)(16)/98.9 = 4 ppm for 75 min inh rat
cyanogen chloride calc (24.5)(3.15)/61.47 = 1.26 ppm
WF6 calculation (24.5)(1430)/298 = 118
CH3Cl calculation (24.5)(5300)/50.5 = 2571 ppm for 4 h rat inh
NO calculation (24.5) (160)/30.1 = 130 ppm but they do not give the time.
(24.5)(1068)/30.1 = 869 ppm for 4 h ---- 1739 ppm calc for 1 h LC50
formaldehyde calculations: (24.5)(480)/30 = 392 (4 h) and multiply by 2 for 1 h ---> 784 ppm
alternate from 1/2 hr LC50 (24.5)(820)/30 = 468 ppm. Well they don't agree but it's not important, they're close enough.
≥ Alt 242
≤ Alt 243